The evolutionary history of vertebrate RNA viruses
The evolutionary history of vertebrate RNA viruses
复制标题
脊椎动物RNA病毒的进化史
DOI：
10.1038/s41586-018-0012-7
复制
发表时间：
2018-04-12
期刊：
影响因子：
64.8
通讯作者：
Zhang, Yong-Zhen
中科院分区：
文献类型：
--
作者：
Shi, Mang;Lin, Xian-Dan;Zhang, Yong-Zhen
我们对脊椎动物RNA病毒的多样性和进化的了解在很大程度上局限于在哺乳动物和鸟类宿主中发现的以及与显性疾病相关的那些病毒。在此，我们利用大规模宏转录组学方法，在爬行动物、两栖动物、肺鱼、辐鳍鱼、软骨鱼和无颌鱼中发现了214种与脊椎动物相关的病毒。新发现的病毒出现在与脊椎动物感染相关的每一个RNA病毒科或属中，包括那些包含人类病原体的病毒，如流感病毒、沙粒病毒科和丝状病毒科，并且其分支顺序大致反映了其宿主的系统发育历史。我们确定了大多数脊椎动物RNA病毒类群的漫长进化历史，并通过使用有年代的直系同源内源性病毒元件评估进化时间尺度来支持这一结论。我们还发现了新的脊椎动物特异性RNA病毒和基因组结构，并重新评估了虫媒RNA病毒的进化。总之，这项研究揭示了脊椎动物整个进化历史中多样的病毒 - 宿主关联。
Our understanding of the diversity and evolution of vertebrate RNA viruses is largely limited to those found in mammalian and avian hosts and associated with overt disease. Here, using a large-scale meta-transcriptomic approach, we discover 214 vertebrate-associated viruses in reptiles, amphibians, lungfish, ray-finned fish, cartilaginous fish and jawless fish. The newly discovered viruses appear in every family or genus of RNA virus associated with vertebrate infection, including those containing human pathogens such as influenza virus, theArenaviridaeandFiloviridaefamilies, and have branching orders that broadly reflected the phylogenetic history of their hosts. We establish a long evolutionary history for most groups of vertebrate RNA virus, and support this by evaluating evolutionary timescales using dated orthologous endogenous virus elements. We also identify new vertebrate-specific RNA viruses and genome architectures, and re-evaluate the evolution of vector-borne RNA viruses. In summary, this study reveals diverse virus–host associations across the entire evolutionary history of the vertebrates.