Do osteocytes contribute to phosphate homeostasis?
Do osteocytes contribute to phosphate homeostasis?
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DOI：
10.1097/mnh.0b013e32832c224f
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发表时间：
2009-07
影响因子：
3.2
通讯作者：
Schiavi S
中科院分区：
文献类型：
--
作者：
Feng JQ;Ye L;Schiavi S
骨细胞是成骨细胞谱系的终末分化细胞，占所有骨细胞的90%以上。由于它们在矿化基质中相对不可及，与充分研究的表面骨细胞、成骨细胞和破骨细胞相比，关于它们的具体功能知之甚少。此外，骨通常被视为矿物质储库，其响应于从远程器官分泌的激素而被动地释放钙和磷酸盐。骨细胞中产生的非胶原基质蛋白，如牙本质基质蛋白1（DMP 1），也被视为钙-磷酸盐沉积的惰性支架。最近发现的新的基因突变在人类疾病和基因工程动物模型的发展挑战这些经典的范例，表明骨细胞在矿化和全身磷酸盐调节中起着积极的作用。在这篇综述中，我们将重点关注骨细胞在矿化中的作用，特别是通过DMP 1-FGF 23途径调节磷酸盐。
Osteocytes, the terminally differentiated cell of the osteoblast lineage, account for over 90% of all bone cells. Due to their relative inaccessibility within mineralized matrix, little is known regarding their specific functions in comparison to the well studied surface bone cells, osteoblasts and osteoclasts. Furthermore, bone is often viewed as a mineral reservoir that passively releases calcium and phosphate in response to hormones secreted from remote organs. Noncollagenous matrix proteins produced in osteocytes, such as dentin matrix protein 1 (DMP1), have also been viewed as inert scaffolds for calcium–phosphate deposition. Recent discoveries of new genetic mutations in human diseases and development of genetically engineered animal models challenge these classic paradigms, suggesting that the osteocyte plays an active role in both mineralization and total systemic phosphate regulation. In this review, we will focus on roles of osteocytes in mineralization and particularly in phosphate regulation via the DMP1-FGF23 pathway.