Measuring serum aminoterminal type III procollagen peptide, 7S domain of type IV collagen, and cardiac troponin T in patients with idiopathic dilated cardiomyopathy and secondary cardiomyopathy
Measuring serum aminoterminal type III procollagen peptide, 7S domain of type IV collagen, and cardiac troponin T in patients with idiopathic dilated cardiomyopathy and secondary cardiomyopathy
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DOI：
10.1136/hrt.78.5.505
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发表时间：
1997-11-01
期刊：
影响因子：
5.7
通讯作者：
Takatsu, Y
中科院分区：
文献类型：
--
作者：
Sato, Y;Kataoka, K;Takatsu, Y
目的：为了确定特发性扩张型心肌病(DCM)和继发性心肌病的新的预后指标。设计和患者-血清III型前胶原氨基末端前肽和IV型胶原7S结构域(7S胶原)-最近被用作其他疾病的胶原基质转换指标-和心肌肌钙蛋白T连续检测17例DCM和4例继发性心肌病(1例合并甲状腺功能亢进，2例合并慢性肾功能衰竭，1例合并淀粉样变性)，并经心内膜心肌活检证实。结果：11例患者中，尽管肌酸激酶浓度在正常范围内，但III型前胶原、7S胶原或肌钙蛋白T仍为阳性。这些患者的短期预后较差(p<；0.001)。结论：在扩张型心肌病和继发性心肌病组中，有一组患者的血清胶原和肌钙蛋白T浓度升高，短期预后较差。尽管目前尚不清楚这些血清多肽水平是否反映了正在进行的心肌细胞变性和间质纤维化，但它们可能成为心肌病有用的新的预后指标。
Objective-To identify new prognostic indicators in idiopathic dilated cardiomyopathy (DCM) and secondary cardiomyopathy.Design and patients-Serum concentrations of aminoterminal propeptides of type III procollagen and the 7S domain of type IV collagen (7S collagen)-which have recently been used as indicators of collagen matrix turnover in other diseases-and of cardiac troponin T were measured in 17 consecutive patients with DCM and in four patients with secondary cardiomyopathy (one associated with hyperthyroidism, two with chronic renal failure, one with amyloidosis), confirmed by endomyocardial biopsy. The correlation of these variables with short term prognosis was then assessed prospectively.Results-11 of the patients were positive for type III procollagen, 7S collagen, or troponin T even though their creatine kinase concentrations were within the normal range. These patients had a poor short term prognosis (p < 0.001).Conclusions-Within the DCM and secondary cardiomyopathy groups, there was a subgroup of patients with raised concentrations of serum collagen and troponin T, for whom short term prognosis was poor. Although it is unclear whether these serum peptide levels reflect ongoing myocyte degeneration and interstitial fibrosis, they may serve as useful new prognostic indicators for cardiomyopathy.