IMMUNOGENICITY AND REACTOGENICITY OF INFLUENZA A-NEW-JERSEY-76 VIRUS-VACCINES IN NORMAL ADULTS
IMMUNOGENICITY AND REACTOGENICITY OF INFLUENZA A-NEW-JERSEY-76 VIRUS-VACCINES IN NORMAL ADULTS
复制标题
DOI：
10.1093/infdis/136.supplement_3.s435
复制
发表时间：
1977-01-01
影响因子：
6.4
通讯作者：
ENNIS, FA
中科院分区：
文献类型：
--
作者：
DOLIN, R;WISE, TG;ENNIS, FA
在一项双盲、安慰剂对照试验中，对199名年龄在19-59岁的正常成年人肌肉注射灭活甲型流感/新泽西/76病毒疫苗，剂量分别为200、400或800鸡细胞凝集单位。全身反应（包括发热）不常见，症状轻微，持续时间<24小时，并且与最大剂量相关。局部反应很常见，但很温和。在接种疫苗2小时后，一名志愿者出现了单一的、迅速可逆的过敏反应。与血清阴性的疫苗接种者相比，血清中预先存在针对疫苗病毒的血凝抑制（HAl）抗体的疫苗接种者有更少的全身反应的趋势。所有三种剂量下的所有疫苗制剂在高比例的血清阴性受体中诱发了大于或等于20至大于或等于40的血清HAl滴度，在最高剂量下具有显着更高的几何平均滴度。年龄在19岁到23岁之间的疫苗接种者的血清学反应明显低于年龄在23岁以上的疫苗接种者。因此，23岁以上的正常成年人可以通过单次耐受性良好的a /新泽西/76疫苗进行免疫。
Inactivated influenza A/New Jersey/76 virus vaccines were administered intramuscularly to 199 normal adults, aged 19–59, in doses of 200, 400, or 800 chick cellagglutinating units in a double-blind, placebo-controlled trial. Systemic reactions (including fever) were uncommon, were mild, lasted <24 hr, and were more frequently associated with the largest dose. Local reactions were common but mild. A single, rapidly reversible, allergic reaction was noted in a volunteer 2 hr after vaccination. There was a trend toward fewer systemic reactions in vaccinees who had preexisting hemagglutination-inhibiting (HAl) antibodies to the vaccine virus in their sera as compared with seronegative vaccinees. All vaccine preparations at all three dosages evoked serum HAl titers of ⩾20 to ⩾40 in a high proportion of seronegative recipients, with significantly greater geometric mean titers at the highest dosage. Vaccinees between the ages of 19 and 23 years manifested significantly lower serologic responses than did vaccinees over the age of 23. Thus, normal adults over the age of 23 can be immunized with a single, well-tolerated dose of A/New Jersey /76 vaccines.