Origin of basal activity in mammalian olfactory receptor neurons
Origin of basal activity in mammalian olfactory receptor neurons
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DOI：
10.1085/jgp.201010528
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发表时间：
2010-11-01
影响因子：
3.8
通讯作者：
Reisert, Johannes
中科院分区：
文献类型：
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作者：
Reisert, Johannes
哺乳动物的气味受体形成了一个大的，不同的G蛋白偶联受体，决定嗅觉受体神经元的敏感性和反应谱。但很少有人知道，如果气味受体控制基础和刺激诱导的嗅觉受体神经元的细胞特性以外的配体特异性。这项研究表明，不同的气味受体有不同程度的基础活动，这驱动伴随受体电流波动和基础动作电位放电。这种基础活性可以被起反向激动剂作用的气味剂抑制。此外，气味刺激的嗅觉受体神经元表达不同的气味受体可以有显着不同的反应模式，在后期阶段的长期刺激。因此，气味受体选择对反应特性的影响比以前认为的要复杂得多，这对气味编码和气味信息向大脑的传递具有重要影响。
Mammalian odorant receptors form a large, diverse group of G protein-coupled receptors that determine the sensitivity and response profile of olfactory receptor neurons. But little is known if odorant receptors control basal and also stimulus-induced cellular properties of olfactory receptor neurons other than ligand specificity. This study demonstrates that different odorant receptors have varying degrees of basal activity, which drives concomitant receptor current fluctuations and basal action potential firing. This basal activity can be suppressed by odorants functioning as inverse agonists. Furthermore, odorant-stimulated olfactory receptor neurons expressing different odorant receptors can have strikingly different response patterns in the later phases of prolonged stimulation. Thus, the influence of odorant receptor choice on response characteristics is much more complex than previously thought, which has important consequences on odor coding and odor information transfer to the brain.