Influence of Statin Therapy on the Incidence of Cardiovascular Events, Cancer, and All-Cause Mortality in People Living With HIV: A Meta-Analysis.
Influence of Statin Therapy on the Incidence of Cardiovascular Events, Cancer, and All-Cause Mortality in People Living With HIV: A Meta-Analysis.
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他汀类药物治疗对艾滋病毒感染者心血管事件、癌症和全因死亡率的影响：荟萃分析
DOI：
10.3389/fmed.2021.769740
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发表时间：
2021
影响因子：
3.9
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Li Y;Wang Z;Xia H;Zhang J
背景资料：他汀类药物治疗对HIV感染者（PLWH）心血管事件、癌症和全因死亡率风险的可能影响尚不清楚。我们进行了一项荟萃分析，以系统地评价他汀类药物在PLWH中的疗效。方法：通过检索Medline、Embase和Web of Science数据库检索相关队列研究，直至2021年6月14日。通过纳入研究间异质性，将数据与随机效应模型相结合。结果如下：共有12项多变量队列研究，162，252名参与者符合荟萃分析的条件，其中36，253名（22.3%）是他汀类药物使用者。汇总结果显示，他汀类药物的使用与PLWH患者死亡风险降低独立相关[校正风险比（RR）：0.56，95%CI：0.44 - 0.72，p < 0.001，I2 = 41%]。此外，荟萃分析的结果显示，与他汀类药物非使用者相比，他汀类药物使用与PLWH心血管事件风险降低无显著相关性（RR：1.14，95% CI：0.80至1.63，p = 0.48，I2 = 42%）。然而，他汀类药物的使用与PLWH中癌症风险的降低显著相关（RR：0.73，95% CI：0.58至0.93，p = 0.009，I2 = 49%）。一次排除一项研究的敏感性分析显示了一致的结果。未观察到显著的出版偏倚。结论：他汀类药物的使用与降低PLWH的全因死亡率相关。此外，他汀类药物的使用与癌症风险降低有关，尽管心血管事件的风险似乎没有显著影响。
Background: Possible influences of statin therapy on the risk of cardiovascular events, cancer, and all-cause mortality in people living with HIV (PLWH) remain unclear. We performed a meta-analysis to systematically evaluate the efficacy of statin in PLWH. Methods: Relevant cohort studies were retrieved via a search of the Medline, the Embase, and the Web of Science databases until June 14, 2021. The data were combined with a random-effects model by incorporating the between-study heterogeneity. Results: A total of 12 multivariate cohort studies with 162,252 participants were eligible for the meta-analysis and 36,253 (22.3%) of them were statin users. Pooled results showed that statin use was independently related to a reduced mortality risk in PLWH [adjusted risk ratio (RR): 0.56, 95% CI: 0.44 to 0.72, p < 0.001, I2 = 41%]. In addition, results of the meta-analysis showed that statin use was not significantly associated with a reduced risk of cardiovascular events in PLWH compared to the statin non-users (RR: 1.14, 95% CI: 0.80 to 1.63, p = 0.48, I2 = 42%). However, statin use was significantly related to a reduced risk of cancer in PLWH (RR: 0.73, 95% CI: 0.58 to 0.93, p = 0.009, I2 = 49%). Sensitivity analyses by excluding one study at a time showed consistent results. No significant publication biases were observed. Conclusion: Statin use is associated with reduced all-cause mortality in PLWH. In addition, statin use is related to a reduced risk of cancer, although the risk of cardiovascular events seems not significantly affected.
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影响因子：
3.8
作者：
Galli, Laura;Spagnuolo, Vincenzo;Castagna, Antonella
通讯作者：
Castagna, Antonella
影响因子：
3.7
作者：
Drechsler H;Ayers C;Cutrell J;Maalouf N;Tebas P;Bedimo R
通讯作者：
Bedimo R
DOI：
10.1097/qai.0b013e318186519c
发表时间：
2008-09-01
影响因子：
3.6
作者：
Kotler, Donald P.
通讯作者：
Kotler, Donald P.
DOI：
10.1097/qad.0000000000002748
发表时间：
2021-02-02
期刊：
AIDS (London, England)
影响因子：
--
作者：
Bedimo RJ;Park LS;Shebl FM;Sigel K;Rentsch CT;Crothers K;Rodriguez-Barradas MC;Goetz MB;Butt AA;Brown ST;Gibert C;Justice AC;Tate JP
通讯作者：
Tate JP
他汀类药物的多效性作用。
影响因子：
--
作者：
Kavalipati N;Shah J;Ramakrishan A;Vasnawala H
通讯作者：
Vasnawala H