Effect of endurance training on coronary artery size and function in healthy men: an invasive followup study
Effect of endurance training on coronary artery size and function in healthy men: an invasive followup study
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DOI：
10.1152/ajpheart.00977.2001
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发表时间：
2002-06-01
影响因子：
4.8
通讯作者：
Seiler, C
中科院分区：
文献类型：
--
作者：
Windecker, S;Allemann, Y;Seiler, C
在8名健康男性志愿者（心脏病专家;年龄36 ± 5岁）中，在完成>5个月持续时间的体能耐力运动计划之前和之后，进行了自行车肺活量测定、多普勒超声心动图和定量冠状动脉造影术以及冠状动脉内多普勒测量。最大摄氧量从46 +/- 6增加到54 +/- 5 ml.kg（-1）.min（-1）（P = 0.04），最大测功负荷从3.8 +/- 0.3改变到4.4 +/- 0.3 W/kg（P = 0.001），左心室质量指数从82 +/- 18增加到108 +/- 29 g/m2（P = 0.001）。右冠状动脉、左主干和左前降支的横截面积在运动后显著增加。运动前和运动结束时，血流诱导的冠状动脉左前降支横截面积分别为10.1 +/- 3.5和11.0 +/- 3.9 mm（2（P = 0.03），硝酸甘油诱导的左冠状动脉口径显著增加，冠状动脉血流储备从3.8 ± 0.8变为4.5 ± 0.7（P = 0.001）。左冠状动脉与心室质量和最大摄氧量显著相关，冠状动脉血流速度储备与最大负荷显著相关。
In eight healthy male volunteers (cardiologists; age 36 +/- 5 yr), bicycle spiroergometry, Doppler echocardiography, and quantitative coronary angiography with intracoronary Doppler measurements before and after completion of a physical endurance exercise program of >5 mo duration were performed. Maximum oxygen uptake increased from 46 +/- 6 to 54 +/- 5 ml.kg(-1).min(-1) (P = 0.04), maximum ergometric workload changed from 3.8 +/- 0.3 to 4.4 +/- 0.3 W/kg (P = 0.001), and left ventricular mass index increased from 82 +/- 18 to 108 +/- 29 g/m(2) (P = 0.001). The right, left main, and left anterior descending coronary artery cross-sectional area increased significantly in repsonse to exercise. Before versus at the end of the exercise program, flow-induced left anterior descending coronary artery cross-sectional area was 10.1 +/- 3.5 and 11.0 +/- 3.9 mm(2), respectively (P = 0.03), nitroglycerin-induced left coronary calibers increased significantly, and coronary flow velocity reserve changed from 3.8 +/- 0.8 to 4.5 +/- 0.7 (P = 0.001). Left coronary artery correlated significantly with ventricular mass and maximum oxygen uptake, and coronary flow velocity reserve was significantly associated with maximum workload.