EBV-Associated Hodgkin's Disease in an HIV-Infected Child Presenting with a Hemophagocytic Syndrome
EBV-Associated Hodgkin's Disease in an HIV-Infected Child Presenting with a Hemophagocytic Syndrome
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患有噬血细胞综合征的 HIV 感染儿童中的 EBV 相关霍奇金病
DOI：
10.3109/10428190109097696
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发表时间：
2001
影响因子：
2.6
通讯作者：
S. Grinstein
中科院分区：
文献类型：
--
作者：
M. V. Preciado;E. Matteo;A. Fallo;P. Chabay;G. Drelichman;S. Grinstein
一名8岁男孩因不明原因发热、颈部淋巴结病、肝脾肿大和体重减轻入院。他的母亲在他住院前两周被诊断出感染艾滋病毒，因此他被诊断为围产期获得性艾滋病。血清学和系列培养对病毒感染、弓形虫病、恰加斯病、结核病和非典型分枝杆菌呈阴性。患者符合噬血细胞综合征（HS）的临床和实验室标准，经骨髓穿刺和活检证实。进行颈部淋巴结活检，诊断为霍奇金病（HD）弥漫性纤维化淋巴细胞耗竭亚型。EBERs原位杂交和LMP-1免疫组织化学对淋巴结活检建立了EBV相关性。根据临床、实验室和组织学体征的出现顺序，HTV、EBV或HD可能触发HS作为该儿科患者的最后致死性事件。
An 8-years-old boy was admitted with fever of unknown origin, cervical lymphadenopathy and hepatosplenomegaly and weight loss. His mother's HIV infection was diagnosed two weeks before his hospitalization, so he was diagnosed as perinatally acquired AIDS. Serology and serial cultures were negative for viral infections, toxoplasmosis, chagas, tuberculosis and atypical mycobacterium. The patient met clinical and laboratory criteria for hemophagocytic syndrome (HS) that was confirmed on bone marrow aspirate and biopsy. A cervical lymph node biopsy was performed which was diagnosed as Hodgkin's disease (HD) diffuse fibrosis lymphocyte depletion subtype. EBERs in situ hybridization and LMP-1 immunohistochemistry on the lymph node biopsy established the EBV association. On the basis of a sequence of appearance of the clinical, laboratory and histological signs, HTV, EBV or HD may have triggered HS as the last fatal event in this pediatric patient.