pH-Responsive near-infrared fluorescent cyanine dyes for molecular imaging based on pH sensing
pH-Responsive near-infrared fluorescent cyanine dyes for molecular imaging based on pH sensing
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DOI：
10.1039/c7cc03035e
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发表时间：
2017-07-14
影响因子：
4.9
通讯作者：
Ohe, Kouichi
中科院分区：
文献类型：
--
作者：
Miki, Koji;Kojima, Kentaro;Ohe, Kouichi
合成了具有亲核取代基的吲哚菁绿色（ICG）衍生物作为pH响应性近红外染料。具有闭环结构的pH响应染料1-C响应于HeLa细胞的酸性细胞内区室中相对低的pH而平滑地内化并转化为发射性开环结构1-O。
Indocyanine green (ICG) derivatives having nucleophilic substituents were synthesized as pH-responsive near-infrared dyes. pH-responsive dyes 1-C with closed-ring structures smoothly internalized and converted to emissive open-ring structures 1-O in response to relatively low pHs in acidic intracellular compartments of HeLa cells.