Comparative effectiveness of pelvic floor muscle training, mirabegron, and trospium among older women with urgency urinary incontinence and high fall risk: a feasibility randomized clinical study.
Comparative effectiveness of pelvic floor muscle training, mirabegron, and trospium among older women with urgency urinary incontinence and high fall risk: a feasibility randomized clinical study.
复制标题
DOI：
10.1186/s40814-023-01440-w
复制
发表时间：
2024-01-04
影响因子：
1.7
通讯作者：
Kilic, Gokhan
中科院分区：
文献类型：
--
作者：
Fisher, Steve R.;Villasante-Tezanos, Alejandro;Allen, Lindsay M.;Pappadis, Monique R.;Kilic, Gokhan
未经治疗的急迫性尿失禁（UUI）和膀胱过度活动症（OAB）会导致身体活动减少、社交孤立、害怕跌倒和福尔斯的恶性循环。结构性行为干预和药物是常见的初始治疗选择，但它们通过非常不同的作用机制产生效果，这些机制可能会不同地影响跌倒相关的结果。这项研究将确定进行一项比较有效性的可行性，三臂，混合方法，随机临床试验的行为为基础的盆底肌肉训练（PFMT）干预与两个最近的药物选择与UUI或OAB的老年妇女谁也在下降的风险增加。将通过我们大学卫生系统的泌尿妇科和盆腔健康诊所招募48名60岁及以上患有UUI或OAB的女性，这些女性筛查出的跌倒风险增加呈阳性。参与者将被随机分配到三个为期12周的治疗组中的一个：（1）由物理治疗师提供的行为和骨盆底肌肉训练（PFMT）课程;（2）β-3激动剂，米拉贝隆;和（3）抗毒蕈碱，曲司氯铵。将通过可评价性、干预依从性和自然减员的客观指标确定研究可行性。我们还将评估OAB症状严重程度、生活质量、体力活动、意外福尔斯和对跌倒的担忧的相关指标。拟议的研究旨在最终确定通过治疗减少UI症状之间的联系是否也降低了该患者人群的跌倒风险。NCT 05880862。于二零二三年五月三十日注册。
Untreated, urgency urinary incontinence (UUI) and overactive bladder (OAB) can precipitate a vicious cycle of decreasing physical activity, social isolation, fear of falling, and falls. Structured behavioral interventions and medications are common initial treatment options, but they elicit their effects through very different mechanisms of action that may influence fall-related outcomes differently. This study will determine the feasibility of conducting a comparative effectiveness, three-arm, mixed methods, randomized clinical trial of a behaviorally based pelvic floor muscle training (PFMT) intervention versus two recent drug options in older women with UUI or OAB who are also at increased risk of falling. Forty-eight women 60 years and older with UUI or OAB who screen positive for increased fall risk will be recruited through the urogynacology and pelvic health clinics of our university health system. Participants will be randomly assigned to one of three 12-week treatment arms: (1) a course of behavioral and pelvic floor muscle training (PFMT) provided by physical therapists; (2) the beta-3 agonist, mirabegron; and (3) the antimuscarinic, trospium chloride. Study feasibility will be established through objective metrics of evaluability, adherence to the interventions, and attrition. We will also assess relevant measures of OAB symptom severity, quality of life, physical activity, incident falls, and concern about falling. The proposed research seeks to ultimately determine if linkages between reduction in UI symptoms through treatment also reduce the risk of falling in this patient population. NCT05880862. Registered on 30 May 2023.
登录
查看更多内容
DOI：
10.1046/j.1532-5415.2001.49094.x
发表时间：
2001-04-01
影响因子：
6.3
作者：
Dugan, E;Roberts, CP;Albertson, E
通讯作者：
Albertson, E
影响因子：
2
作者：
Dumoulin, Chantale;Glazener, Cathryn;Jenkinson, David
通讯作者：
Jenkinson, David
影响因子：
6.7
作者：
Delbaere, Kim;Close, Jacqueline C. T.;Lord, Stephen R.
通讯作者：
Lord, Stephen R.
影响因子：
3.5
作者：
Fraser, Sarah A.;Elliott, Valerie;Dumoulin, Chantal
通讯作者：
Dumoulin, Chantal
影响因子：
6.6
作者：
Burgio, Kathryn L.;Goode, Patricia S.;Redden, David T.
通讯作者：
Redden, David T.