Alzheimer's disease and its focal variants
Alzheimer's disease and its focal variants
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DOI：
10.1055/s-2000-13177
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发表时间：
2000-01-01
影响因子：
2.7
通讯作者：
Miller, BL
中科院分区：
文献类型：
--
作者：
Kramer, JH;Miller, BL
阿尔茨海默病(AD)是老年人中最常见的痴呆症。虽然AD的诊断需要病理证实，但已经确定了AD的几个常见临床特征。这些症状包括潜伏性发作、渐进性进展、内侧颞叶萎缩、顶叶低灌注量、早期和显著的情景记忆和心理追踪缺陷，以及后来的语义记忆缺陷。AD的这些特征使其具有出色的活体诊断灵敏度。然而，越来越清楚的是，阿尔茨海默病是一种异质性疾病。左右大脑半球都会受到不同程度的影响，也有关于前后轴变异的报道。AD也可以表现为局灶性退行性疾病，临床医生必须意识到AD、原发性进行性失语、后部皮质萎缩、皮质基底膜变性和额颞部痴呆之间可能存在诊断重叠。
Alzheimer's disease (AD) is the most common form of dementia in elderly individuals. Although the diagnosis of AD requires pathological confirmation, several common clinical features of AD have been identified. These include insidious onset, gradual progression, medial temporal atrophy, temporoparietal hypoperfusion, early and prominent deficits in episodic memory and mental tracking, and later deficits in semantic memory. These characteristic features of AD have enabled excellent in vivo diagnostic sensitivity. It has become increasingly clear, however, that AD is a heterogeneous disorder. The left and right cerebral hemispheres can be affected to varying degrees, and variability on the anterior-posterior axis has also been reported. AD can also present as a focal degenerative disease, and clinicians must be aware that there may be diagnostic overlap between AD, primary progressive aphasia, posterior cortical atrophy, corticobasal degeneration, and frontotemporal dementia.