Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 and ArmA 16S rRNA methylase conferring high-level aminoglycoside resistance in carbapenem-resistant Enterobacter cloacae in China
Plasmid-mediated carbapenem-hydrolyzing enzyme KPC-2 and ArmA 16S rRNA methylase conferring high-level aminoglycoside resistance in carbapenem-resistant Enterobacter cloacae in China
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DOI：
10.1016/j.diagmicrobio.2009.10.003
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发表时间：
2010-03-01
影响因子：
2.9
通讯作者：
Ni, Yuxing
中科院分区：
文献类型：
--
作者：
Wu, Qiong;Liu, Qingzhong;Ni, Yuxing
世界范围内耐碳青霉烯类肠杆菌科细菌的出现和传播是一个主要问题。我们研究了 5 株阴沟肠杆菌分离株，它们对除多粘菌素 B 之外的所有临床可用抗菌药物均具有耐药性。亚胺培南和氨基糖苷类抗生素的 MIC 分别为 >32 和 >256 mg/L。分别。所有分离株均产生 5 种超广谱 β-内酰胺酶 (ESBL)，pIs 分别为 5.4 (TEM-1)、6.7 (KPC-2)、8.2 (SHV-12)、8.4 (CTX-M-14) 和 ArmA 16S rRNA 甲基化酶。 bla(KPC-2) 位于一个大的非接合质粒上，而armA 位于另一个接合质粒上。尽管耐碳青霉烯类肠杆菌科细菌仍然很少见，但这类生物体的出现值得监测。 (C) 2010 Elsevier Inc. 保留所有权利。
The emergence and spread of carbapenem-resistant Enterobacteriaceae in the world are a major concern. We investigated 5 isolates of Enterobacter cloacae that were resistant to all clinically available antimicrobial agents, except polymyxin B. The MICs of imipenem and aminoglycosides were >32 and >256 mg/L. respectively. All of the isolates produced 5 extended-spectrum beta-lactamase (ESBLs) with pIs of 5.4 (TEM-1), 6.7 (KPC-2), 8.2 (SHV-12), 8.4 (CTX-M-14), and ArmA 16S rRNA methylase. bla(KPC-2) was located on a large nonconjugative plasmid, whereas armA was located on another conjugative plasmid. Although carbapenem-resistant Enterobacteriaceae remains rare, the emergence of this group of organism merits monitoring. (C) 2010 Elsevier Inc. All rights reserved.