Transport of calcium by duodenum of spontaneously hypertensive rat.
Transport of calcium by duodenum of spontaneously hypertensive rat.
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自发性高血压大鼠十二指肠的钙转运。
DOI：
10.1152/ajpgi.1981.241.4.g344
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
G. Wright
中科院分区：
文献类型：
--
作者：
M. Toraason;G. Wright
本实验测定了自发性高血压（SH）大鼠和正常血压Wistar-Kyoto（WKy）大鼠在高血压形成前后十二指肠对钙的吸收。5周龄SH大鼠的收缩压（SBP）（116 +/- 4 Torr）显著高于年龄匹配的WKy大鼠（103 +/- 3 Torr），但未达到通常认为的高血压水平。从外翻的十二指肠囊获得的钙转运值[血清与粘膜液45 Ca 2+浓度的比值（S/M比值）]在该年龄两组之间相似。在12周龄时，SH大鼠的SBP（153 +/- 4 Torr）远高于WKy对照组（127 +/- 3 Torr），十二指肠囊的钙S/M比显著大于WKy对照值。同样，与WKy对照组相比，12周龄SH大鼠体内十二指肠段钙摄取显著升高。维生素D3或其代谢产物25-羟基胆钙化醇的给药对12周龄SH或WKy大鼠的十二指肠钙转运没有可检测到的影响。相比之下，1，25-二羟基胆钙化醇在WKy大鼠体内和体外均显著增加了十二指肠钙转运，但在SH大鼠中没有。结果表明，在SH大鼠的十二指肠中的钙的运输的一个明显的异常，这表明，通常发生的成熟的十二指肠中的钙摄取的减少是缓慢的发展，在这种大鼠品系。
The absorption of calcium by segments of duodenum obtained from spontaneously hypertensive (SH) rats and normotensive Wistar-Kyoto (WKy) rats was measured before and after the development of hypertension. The systolic blood pressure (SBP) of 5-wk-old SH rats (116 +/- 4 Torr) was significantly elevated above that of age-matched WKy rats (103 +/- 3 Torr) but was not at a level generally considered to be hypertensive. Values obtained for calcium transport [ratio of serosal-to-mucosal fluid 45Ca2+ concn (S/M ratio)] from everted duodenal sacs were similar between the two groups at this age. At 12 wk of age, SH rats exhibited a SBP (153 +/- 4 Torr) well above that of WKy controls (127 +/- 3 Torr), and calcium S/M ratios for duodenal sacs were significantly greater than the WKy control values. Similarly, the in vivo uptake of calcium in duodenal segments was significantly elevated in 12-wk-old SH rats compared with WKy controls. The administration of vitamin D3 or its metabolite, 25-hydroxycholecalciferol, had no detectable effect on duodenal transport of calcium in 12-wk-old SH or WKy rats. By comparison, 1,25-dihydroxycholecalciferol produced a significant increase in duodenal calcium transport both in vitro and in vivo in WKy but not in SH rats. The results indicate a distinct abnormality in the transport of calcium in the duodenum of SH rats, suggesting that the decrease in duodenal uptake of calcium that normally occurs with maturation is slow to develop in this rat strain.