Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study
Prevalence and clinical implications of sarcopenic obesity in patients with solid tumours of the respiratory and gastrointestinal tracts: a population-based study
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DOI：
10.1016/s1470-2045(08)70153-0
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发表时间：
2008-07-01
期刊：
影响因子：
51.1
通讯作者：
Baracos, Vickie E.
中科院分区：
文献类型：
--
作者：
Prado, Carla M. M.;Liefers, Jessica R.;Baracos, Vickie E.
研究背景：身体组成的新证据表明，肌肉减少性肥胖（肌肉质量减少的肥胖）可能预示着非恶性疾病的发病率和死亡率，也预示着化疗的毒性。我们的目的是评估的患病率和cancer.Methods 1月13日至2007年1月19日，2115例实体瘤的呼吸道或胃肠道癌症治疗中心服务北方阿尔伯塔，加拿大，患者的sacroopenic肥胖的临床意义。对肥胖患者的腰椎CT图像进行分析，以获得总骨骼肌横截面积;这些值也用于估计全身无脂肪质量（FFM）。在这些肥胖患者中，250例的CT图像符合分析标准。其余75例患者记录为无可评估扫描。肥胖患者的肌肉质量范围很广。通过最佳分层分析确定了定义低肌肉质量与死亡率之间显著相关性的性别特异性截止值：250例具有符合分析标准的可评估CT图像的患者中有38例（15%）低于这些截止值，并被归类为肌肉减少症。与无肌肉减少症的肥胖患者相比，肌萎缩性肥胖患者的功能状态较差（p=0.009），是生存率的独立预测因素（风险比[HR] 4.2 [95%CI 2.4-7-2]，p
Background Emerging evidence on body composition suggests that sarcopenic obesity (obesity with depleted muscle mass) might be predictive of morbidity and mortality in non-malignant disease and also of toxicity to chemotherapy. We aimed to assess the prevalence and clinical implications of sarcopenic obesity in patients with cancer.Methods Between Jan 13, 2004, and Jan 19, 2007, 2115 patients with solid tumours of the respiratory or gastrointestinal tract from a cancer treatment centre serving northern Alberta, Canada, were identified. Available lumbar CT images of the obese patients were analysed for total skeletal muscle cross-sectional area; these values were also used to estimate total body fat-free mass (FFM).Findings Of the 2115 patients initially identified, 325 (15%) were classified as obese (body-mass index [BMI] >= 30). Of these obese patients, 250 had CT images that met the criteria for analysis. The remaining 75 patients were recorded as without assessable scans. Obese patients had a wide range of muscle mass. Sex-specific cut-offs that defined a significant association between low muscle mass with mortality were ascertained by optimum stratification analysis: 38 (15%) of 250 patients who had assessable CT images that met the criteria for analysis were below these cut-offs and were classified as having sarcopenia. Sarcopenic obesity was associated with poorer functional status compared with obese patients who did not have sarcopenia (p=0.009), and was an independent predictor of survival (hazard ratio [HR] 4.2 [95% CI 2.4-7-2], p