Initial events in radiation-induced atheromatosis. IV. Lipid composition of radiation-induced plaques.
Initial events in radiation-induced atheromatosis. IV. Lipid composition of radiation-induced plaques.
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辐射引起的动脉粥样硬化的初始事件。
DOI：
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发表时间：
1980
期刊：
影响因子：
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通讯作者：
H. Lamberts
中科院分区：
文献类型：
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作者：
A. Konings;C. S. Smit Sibinga;H. Lamberts
电离辐射在高脂血症家兔的颈动脉中产生粥样硬化，这些家兔在6周内接受0.5%胆固醇饮食。在这个相对较短的喂养期内，未照射的颈动脉中没有形成粥样硬化。当动物接受这种饮食5个月或2%胆固醇饮食3个月时，在后者的血管中也可以发现饮食诱导的动脉粥样化。比较饮食诱导和辐射诱导的脂肪斑块的脂质组成。在所有类型的斑块中，中性脂质约占总脂质的75%，酯化胆固醇是其主要组成部分，其次是游离胆固醇、磷脂酰胆碱和鞘磷脂。饮食诱导的颈动脉、主动脉脂肪斑块和辐射诱导的脂肪斑块的脂质组成之间存在很大的相似性。结论：辐射是大血管粥样硬化过程中的起始因素之一，由于内皮损伤而导致脂质浸润。
Ionizing irradiation produced atheromas in the carotid arteries of hypercholesteremic rabbits which received a 0.5% cholesterol diet during 6 weeks. During this relatively short feeding period no atheromas were formed in the nonirradiated carotid arteries. When the animals received this diet for 5 months or a 2% cholesterol diet for 3 months also diet-induced atheromatosis could be found in the latter blood-vessels. A comparison was made between the lipid composition of the diet-induced and the radiation-induced fatty plaques. In all types of plaques the neutral lipids formed about 75 percent of the total lipids, esterified cholesterol being formed the main part of it followed by free cholesterol, phosphatidylcholine and sphingomyelin. A great similarity exists between the lipid composition of the diet-induced fatty plaques of the carotid artery, the aorta and the radiation-induced fatty plaque. It is concluded that radiation is one of the initiating factors in the atheromatous process of the large blood-vessels, leading to lipid infiltration because of injury to the endothelium.