Conversion of (sp3)C-F bonds of alkyl fluorides to (sp3)C-heteroatom (heteroatom = I, SR, SeR, TeR) bonds by the use of magnesium reagents having heteroatom substituents
Conversion of (sp3)C-F bonds of alkyl fluorides to (sp3)C-heteroatom (heteroatom = I, SR, SeR, TeR) bonds by the use of magnesium reagents having heteroatom substituents
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DOI：
10.1246/cl.2007.196
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发表时间：
2007-01-05
影响因子：
1.6
通讯作者：
Kambe, Nobuaki
中科院分区：
文献类型：
--
作者：
Begum, Shameem Ara;Terao, Jun;Kambe, Nobuaki
本文提出了一种将（sp（3））C-F键转化为（sp（3））C-Z（Z = I，SR，SeR，TeR）键的简便方法。反应在室温下使用镁盐（Z-MgX）进行。在醚溶液中，Mg I_2取代伯烷基氟的S（N）_2机理得到了与F相连的碳的立体化学反转的支持。
A convenient method for conversion of (sp(3))C-F bonds to (sp(3))C-Z (Z = I, SR, SeR, TeR) bonds has been developed. The reaction proceeds at room temperature using magnesium salts (Z-MgX). S(N)2 mechanism for substitiution of primary alkyl fluorides with MgI2 in ether was supported by the inversion of the stereochemistry of the carbon connecting to F.