Ontogenesis of gonadotropin-releasing hormone neurons: a model for hypothalamic neuroendocrine cell development.
Ontogenesis of gonadotropin-releasing hormone neurons: a model for hypothalamic neuroendocrine cell development.
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DOI：
10.3389/fendo.2013.00089
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发表时间：
2013
影响因子：
5.2
通讯作者：
Chung WC
中科院分区：
文献类型：
--
作者：
Stevenson EL;Corella KM;Chung WC
脊椎动物下丘脑-垂体-性腺轴是负责生殖能力和物种繁殖的解剖框架。这三层生物系统的协调行动至关重要的是，调节输入最终集中在促性腺激素释放激素（GnRH）神经元系统，在啮齿动物中主要位于视前区/下丘脑区域。在这篇简短的综述中，我们将重点关注：（1）啮齿动物GnRH神经元系统的一般胚胎时间和空间发育，（2）GnRH神经元的起源，（3）已发现哪些转录和生长因子对GnRH神经元个体发育和细胞命运特化至关重要。此外，我们问的问题是否参与GnRH神经元发育的分子和细胞机制也可能在下丘脑其他垂体分泌神经内分泌细胞的发展中发挥作用。
The vertebrate hypothalamo–pituitary–gonadal axis is the anatomical framework responsible for reproductive competence and species propagation. Essential to the coordinated actions of this three-tiered biological system is the fact that the regulatory inputs ultimately converge on the gonadotropin-releasing hormone (GnRH) neuronal system, which in rodents primarily resides in the preoptic/hypothalamic region. In this short review we will focus on: (1) the general embryonic temporal and spatial development of the rodent GnRH neuronal system, (2) the origin(s) of GnRH neurons, and (3) which transcription – and growth factors have been found to be critical for GnRH neuronal ontogenesis and cellular fate-specification. Moreover, we ask the question whether the molecular and cellular mechanisms involved in GnRH neuronal development may also play a role in the development of other hypophyseal secreting neuroendocrine cells in the hypothalamus.