COVID-19: beta-thalassemia subjects immunised?
COVID-19: beta-thalassemia subjects immunised?
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DOI：
10.1016/j.mehy.2020.109827
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发表时间：
2020-09-01
影响因子：
4.7
通讯作者：
Son-Forget, Joachim
中科院分区：
文献类型：
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作者：
Lansiaux, Edouard;Pebay, Philippe Pierre;Son-Forget, Joachim
新型冠状病毒肺炎（COVID-19）是一种接触性急性呼吸道传染病，其病原体已被证明是冠状病毒家族的新型病毒SARSCoV-2。最近的一项印刷前研究显示，COVID 19对血红蛋白的1-β链进行了血红素攻击。β-地中海贫血是由于血红蛋白β链合成的缺陷造成的。1.5%的全球人口是这种疾病的杂合子。在这项研究中，通过多元线性回归，我们分析了意大利三个β-地中海贫血患病率不同的地区（普利亚、撒丁岛、西西利亚）COVID-19感染的演变，以寻找联系。结果显示，通过回归分析，β地中海贫血杂合子人群患病率与COVID-19免疫力相关。本文仅作学术探讨，所提出的假设和结论还有待进一步的研究证实。
The novel coronavirus pneumonia (COVID-19) is a contagious acute respiratory infectious disease whose causative agent has been demonstrated to be a novel virus of the coronavirus family, SARSCoV-2. A recent PRE-print study has showed a heme attack on the 1-beta chain of hemoglobin by COVID19. Beta-thalassemia results of a default in the hemoglobin beta-chain synthesis. 1,5% global population are heterozygotes for this disease. In this study, by a multiple linear regression, we have analyzed the evolution of COVID-19 infection in three Italian regions (Puglia, Sardinia, Sicilia) with different beta-thalassemic prevalences, in order to search a link. The results have showed that betathalassemic heterozygote population prevalence is correlated to immunity against COVID-19, by a regression. This paper is only for academic discussion, the hypotheses and conclusions needs to be confirmed by further research.