Humidifier-associated disease in the general population:: a retrospective investigation
Humidifier-associated disease in the general population:: a retrospective investigation
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DOI：
10.1055/s-2006-932548
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发表时间：
2006-03-10
影响因子：
0.6
通讯作者：
Sennekamp, HJ
中科院分区：
文献类型：
--
作者：
Müller-Wening, D;Koschel, D;Sennekamp, HJ
背景与目的：近年来，越来越多的患者出现与接触一种新型国产超声加湿器相关的发热和呼吸道症状。患者和方法：我们报告了14例患者（5名女性，9名男性，平均年龄42.5±17.4岁）在家中多次暴露于超声雾化喷泉后出现反复发作的发烧、咳嗽和呼吸困难。结果：根据病史及临床、放射学、实验室和免疫学检查结果，诊断为外源性过敏性肺泡炎（加湿器肺：12例）或中毒性肺泡炎（加湿器热：2例）。休息或运动时部分呼吸功能不全10例，限制性呼吸异常9例。胸部x线异常7例。在做计算机断层扫描的8例患者中，6例有外源性过敏性肺泡炎的典型变化。支气管肺泡灌洗显示淋巴细胞性肺泡炎8例。在12例患者中，在他们使用的加湿器液中发现了细菌、霉菌和/或酵母菌。13例患者对加湿器液有IgG抗体。8例患者对自己的超声雾化喷泉进行了吸入激发试验，均有阳性反应。结论：这些病例证明了超声波加湿装置在家庭中引起疾病的潜力。鉴于加湿器肺和加湿器热越来越受欢迎，在不明原因肺部或流感样疾病伴发烧患者的鉴别诊断中应考虑加湿器肺和加湿器热。
Background and objective: Recently an increasing number of patients presented with febrile and respiratory symptoms associated with exposure to a new type of domestic ultrasonic humidifier.Patients and methods: We report on 14 patients (5 females, 9 males: average age 42.5 +/- 17.4 years) with recurrent episodes of fever, cough and dyspnea after repeated exposure to ultrasonic misting fountains at home.Results: A diagnosis of extrinsic allergic alveolitis (humidifier lung: 12 patients) or toxic alveolitis (humidifier fever: 2 patients) was made on the basis of the history and the clinical, radiological, laboratory and immunological findings. 10 patients had a partial respiratory insufficiency at rest or on exercise, 9 had a restrictive ventilatory abnormality. The chest x-ray was abnormal in 7 patients. Of 8 patients in whom computed tomography was done 6 had typical changes of an exogenous allergic alveolitis. Bronchoalveolar lavage revealed lymphocytic alveolitis in 8 patients. In 12 patients bacteria, moulds and/or yeasts were demonstrated in the humidier fluid which they had used. 13 patients had IgG antibodies to the humidier fluid. 8 patients were subjected to inhalative challenge tests to their own ultrasonic misting fountain: all of them had positive reactions.Conclusions: These cases demonstrate the potential of ultrasonic humidifying devices to cause illness in the home. In view of their increasing popularity, humidifier lung and humidifier fever should be considered in the differential diagnosis of patients with unexplained pulmonary or flu-like illness with fever.