EFFECT OF BILE SALT-BINDING RESINS ON THE MORPHOLOGY OF RAT JEJUNUM AND COLON - A SCANNING ELECTRON-MICROSCOPY STUDY
EFFECT OF BILE SALT-BINDING RESINS ON THE MORPHOLOGY OF RAT JEJUNUM AND COLON - A SCANNING ELECTRON-MICROSCOPY STUDY
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DOI：
10.1007/bf01315212
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发表时间：
1980-01-01
影响因子：
3.1
通讯作者：
VAHOUNY, GV
中科院分区：
文献类型：
--
作者：
CASSIDY, MM;LIGHTFOOT, FG;VAHOUNY, GV
膳食纤维的一个机制是其螯合胆汁盐的能力，这可能是膳食纤维降低血糖的作用。由于胆盐改变肠道结构，研究了几种常用的外源性胆盐结合剂的形态学效应。Wistar大鼠自由采食含2%消胆胺、2%考来替泊或2% DEAE-Sephadex的纯饲料6周。在体外使用牛磺胆酸盐和甘氨胆酸盐测试这些物质的胆盐结合能力。在体内喂养的树脂的效果是引起的空肠和结肠粘膜的超微结构地形从控制外观的偏差。结肠细胞损伤比在考来替泊和DEAE-Sephadex喂养的动物的空肠中观察到的更严重，而在考来烯胺喂养的大鼠中则相反。在每种条件下的扭曲程度与胆盐结合能力的程度在体外呈正相关。两种作用在严重程度增加方面的等级顺序为DEAE-Sephadex <考来替泊<考来烯胺。
One mechanism suggested to account for the hypocholesteremic effect of dietary fibers is their ability to sequester bile salts. Since bile salts alter intestinal structure, the morphological effects of several commonly used, xenobiotic, bile salt-binding agents was investigated. Wistar rats were fed a purified stock diet, ad lib, for 6 wk containing either 2% cholestyramine, 2% colestipol or 2% DEAE-Sephadex. The bile salt-binding capacity of these substances was tested in vitro using taurocholate and glycocholate. The effect of in vivo feeding of the resins was to evoke ultrastructural topographical deviations from control appearance in both jejunal and colonic mucosae. Colonic cell injury was more severe than that observed in the jejunum of both colestipol- and DEAE-Sephadex-fed animals while the reverse was true for the rats fed cholestyramine. The degree of distortion in each condition was positively correlated with the extent of bile salt-binding capability in vitro. The rank order of both effects in terms of increasing severity was DEAE-Sephadex < colestipol < cholestyramine.