TSL-1 antigens of Trichinella:: An overview of their potential role in parasite invasion, survival and serodiagnosis of trichinellosis
TSL-1 antigens of Trichinella:: An overview of their potential role in parasite invasion, survival and serodiagnosis of trichinellosis
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DOI：
10.1016/j.rvsc.2006.01.002
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发表时间：
2006-12-01
影响因子：
2.4
通讯作者：
del Corral Bezara, L.
中科院分区：
文献类型：
--
作者：
Bolas-Fernandez, F.;del Corral Bezara, L.
大多数旋毛虫属物种的免疫生物学研究集中在幼虫肌相（L1），以确定位于表皮表面和幼虫分泌物中的免疫显性抗原;寄生虫-宿主相互作用的核心。这些抗原被分为8组（TSL-1-TSL-8），其中属于TSL-1组的抗原已被最深入地研究。主要成分是糖蛋白，含有一种不寻常的糖，泰维糖（3，6-二脱氧-D-阿拉伯己糖）的聚糖载体。旨在改进检测旋毛虫病的血清学诊断技术的研究表明，这些抗原是理想的候选抗原。它们能够诱导强烈的体液反应，包括产生针对β-泰维糖的特异性抗体，β-泰维糖是一种似乎专属于鞭毛虫的糖。此外，这些糖蛋白似乎在寄生虫在肌肉生态位的发育和维持中发挥重要作用，并且它们似乎是肠上皮入侵的基础。还证明了针对泰维糖的特异性单克隆抗体可通过称为快速排出的现象介导大鼠中一定程度的免疫保护。(c)2006爱思唯尔有限公司保留所有权利。
The majority of studies on the immunobiology of Trichinella species have centred on the larval muscular phase (L1) with a view to identifying immunodominant antigens located on the surface of the cuticle and in the larval secretions; the nucleus of the parasite-host interaction. These antigens have been classified as eight groups (TSL-1-TSL-8), of which those belonging to the group TSL-1 have been most intensely studied. The principal constituents are glycoproteins, glycan carriers that contain a unusual sugar, the tyvelose (3,6-dideoxy-D-arabinohexose). Studies aimed at improving serodiagnostic techniques to detect trichinellosis indicate that these antigens are ideal candidates. They are capable of inducing a strong humoral response involving the generation of specific antibodies against beta-tyvelose, a sugar that seems to be exclusive to the Trichuroidea. Furthermore, these glycoproteins appear to fulfil an important function in the development and maintenance of the parasite in the muscular niche, and they appear to be fundamental for the invasion of the intestinal epithelium. It has also been demonstrated that specific monoclonal antibodies against tyvelose can mediate a degree of immunoprotection in the rat through the phenomenon known as rapid expulsion. (c) 2006 Elsevier Ltd. All rights reserved.