Cancer Therapy Empowered by Extracellular Vesicle-Mediated Targeted Delivery
Cancer Therapy Empowered by Extracellular Vesicle-Mediated Targeted Delivery
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DOI：
10.1248/bpb.b23-00378
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Yongqiang Li
中科院分区：
文献类型：
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作者：
Yong Chen;Yujuan Huang;Yayan Deng;Xue Liu;Jiaxiang Ye;Qiuyun Li;Yue Luo;Yan Lin;Rong Liang;Jiazhang Wei;Jinyan Zhang;Yongqiang Li
Extracellular vesicles (EVs) are a class of nanoparticles that mediate signaling molecules delivery between donor and recipient cells. Heterogeneity in the content of EVs and their membrane surface proteins determines their unique targetability. Their low immunogenicity, capability to cross various biological barriers, and superior biocompatibility enable engineering-modified EVs to be ideal drug delivery carriers. In addition, the engineered EVs that emerge in recent years have become a powerful tool for cancer treatment through the selective delivery of bioactive molecules to therapeutic targets, such as tumor cells and stroma. Our review focuses on the various types of EV modifications and their promoting therapeutic capabilities, which provide an innovative means for cancer precision therapy.
