Silylethynyl Substituents as Porphyrin Protecting Groups for Solubilization and Selectivity Control K. Oda, M. Akita, S.
Silylethynyl Substituents as Porphyrin Protecting Groups for Solubilization and Selectivity Control K. Oda, M. Akita, S.
复制标题
甲硅烷基乙炔基取代基作为卟啉保护基团用于增溶和选择性控制 K. Oda, M. Akita, S.
作者：
T. Sommerfeld;M. Ehara;K. Oda
甲硅烷基乙炔基取代基被提议作为卟啉衍生物的保护基团，以增强其溶解度并实现区域选择性功能化。用作保护基后，在表面活性剂存在下与 H2SO4 水溶液一起加热，可以有效去除内位的甲硅烷基乙炔基。该方法适用于制备常规方法无法获得的不对称β-取代卟啉和卟啉-卟啉低聚物。
Silylethynyl substituents are proposed as protecting groups for porphyrin derivatives to enhance their solubility and enable regioselective functionalization. After usage as protecting groups, silylethynyl groups at themeso-positions can be efficiently removed upon heating with aqueous H2SO4in the presence of a surfactant. This approach was applied to the preparation of unsymmetrically β-substituted porphyrins and porphin–porphyrin oligomers, which were inaccessible by conventional methods.