HYPERSENSITIVITY REACTIONS IN SMALL-INTESTINE .1. THYMUS DEPENDENCE OF EXPERIMENTAL PARTIAL VILLOUS ATROPHY
HYPERSENSITIVITY REACTIONS IN SMALL-INTESTINE .1. THYMUS DEPENDENCE OF EXPERIMENTAL PARTIAL VILLOUS ATROPHY
复制标题
DOI：
10.1136/gut.16.2.114
复制
发表时间：
1975-01-01
期刊：
影响因子：
24.5
通讯作者：
JARRETT, EEE
中科院分区：
文献类型：
--
作者：
FERGUSON, A;JARRETT, EEE
感染巴西尼波圆线虫的大鼠在小肠受感染区域出现隐窝增生和绒毛萎缩。在胸腺剥夺(B)大鼠中，感染过程延长，但尽管在肠腔中存在许多蠕虫，绒毛和隐窝却基本正常。这表明与巴西乳线虫感染相关的组织损伤不是由蠕虫引起的，而是由局部胸腺依赖的免疫反应引起的。有证据表明淋巴细胞而不是抗体参与了这一反应。我们已经知道，t细胞相关的小肠损伤，如发生在同种异体移植排斥反应中，会产生几乎全部绒毛萎缩。目前的研究结果表明，当T细胞与蠕虫抗原局部反应时，会发生类似类型的损伤。局部细胞介导的免疫反应可能是导致许多小肠疾病（如病毒性肠炎、贾第虫病、牛奶过敏和乳糜泻）中绒毛萎缩和隐窝增生的共同因素。
Rats infected with the intestinal nematode Nippostrongylus brasiliensis have crypt hyperplasia with villous atrophy in affected areas of the small intestine. In thymus-deprived (B) rats the course of infection is prolonged but, despite the presence of many worms in the intestinal lumen, villi and crypts appear largely normal. This suggests that the tissue damaged associated with N. brasilliensis infection is caused, not by the worms, but by a local thymus-dependent immune reaction. There is some evidence to implicate lymphocytes rather than antibodies in this reaction. It is already know that T-cell-associated damage to the small intestine, such as occurs in allograft rejection, produces subtotal villous atrophy. The present findings suggest that when T cell react locally with helminth antigens a similar type of damage occurs. The presence of a local cell-mediated immune reaction may be the common factor which causes villous atrophy and crypt hyperplasia in many small intestinal diseases, eg, viral enteritis, giardiasis, cow's milk allergy, and coeliac disease.