Prevalence of antibodies to Japanese encephalitis virus among pigs in Bali and East Java, Indonesia, 2008.
Prevalence of antibodies to Japanese encephalitis virus among pigs in Bali and East Java, Indonesia, 2008.
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2008 年印度尼西亚巴厘岛和东爪哇猪群中日本脑炎病毒抗体的流行情况。
DOI：
10.7883/yoken.63.58
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发表时间：
2010
期刊：
影响因子：
--
通讯作者：
E. Konishi
中科院分区：
文献类型：
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作者：
A. Yamanaka;K. C. Mulyatno;Helen Susilowati;Eryk Hendrianto;Takako Utsumi;M. Amin;M. Lusida;S. Soegijanto;E. Konishi
日本脑炎病毒（JEV）是亚洲的一种致命疾病。猪被认为是国内环境中JEV的有效扩增宿主。印度尼西亚的巴厘岛和爪哇岛提供了一个模型来评估猪对JEV传播的影响，因为巴厘岛的猪密度比爪哇岛高近100倍，而这些地区的地理和气候环境相当。2008年，我们通过血凝抑制（HAI）试验对Mengwi（巴厘岛）的123头猪和Tulungagung（东爪哇）的96头猪进行了JEV抗体调查。巴厘岛和爪哇岛的总体患病率分别为49%和6%，两者之间存在显著差异（P < 0.001）。根据年龄依赖性抗体流行率估计，巴厘岛的月感染率为11%，爪哇为2%。此外，2-巯基乙醇敏感的抗体只发现从巴厘样品。此外，从阳性样本中获得的平均HAI抗体滴度在巴厘岛（1：52）显著高于爪哇（1：10; P < 0.001）。这些结果表明，JEV在自然界中的传播在巴厘岛比东爪哇更活跃。
Japanese encephalitis virus (JEV) is a fatal disease in Asia. Pigs are considered to be the effective amplifying host for JEV in the peridomestic environment. Bali Island and Java Island in Indonesia provide a model to assess the effect of pigs on JEV transmission, since the pig density is nearly 100-fold higher in Bali than Java, while the geographic and climatologic environments are equivalent in these areas. We surveyed antibodies to JEV among 123 pigs in Mengwi (Bali) and 96 pigs in Tulungagung (East Java) in 2008 by the hemagglutination-inhibition (HAI) test. Overall prevalences were 49% in Bali and 6% in Java, with a significant difference between them (P < 0.001). Monthly infection rates estimated from age-dependent antibody prevalences were 11% in Bali and 2% in Java. In addition, 2-mercaptoethanol-sensitive antibodies were found only from Bali samples. Further, the average HAI antibody titer obtained from positive samples was significantly higher in Bali (1:52) than Java (1:10; P < 0.001). These results indicated that JEV transmission in nature is more active in Bali than East Java.