Accelerated hydrazone formation in charged microdroplets
Accelerated hydrazone formation in charged microdroplets
复制标题
DOI：
10.1002/rcm.7664
复制
发表时间：
2016-08-30
影响因子：
2
通讯作者：
Cooks, R. Graham
中科院分区：
文献类型：
--
作者：
Bain, Ryan M.;Pulliam, Christopher J.;Cooks, R. Graham
电喷雾电离质谱（ESI-MS）是一种新兴的反应监测工具。它可以伴随着在带电droplets. MethodsIndoline-2，3-dione与苯肼在甲醇中的本体反应生成3-（2- phenylhydrazono）indolin-2-one的时间过程中的荷电droplets. MethodsIndoline-2，3-dione是由ESI监测。本研究使用nanoESI和超声喷雾电离（ESSI）作为反应监测的两种常见电离形式。的液滴之间的源和MS入口的行程的距离对产品收率的影响是不同的，产品/起始材料的比例进行了examined.ResultsProduct收率显着增加的距离。在短距离处，可以在没有加速的情况下进行反应监测，并且在更大的距离处发生反应加速。在反应过程中的这种距离效应大致平行的体相reaction.ConclusionsReaction加速液滴中的时间依赖性是由于溶剂蒸发导致增加的表面体积比。在短时间内相对于本体反应测量的加速因子为10（4），通过简单地增加液滴的飞行距离可以容易地实现，这表明可以使用相同的电离源来监测具有或不具有加速的反应。版权所有（c）2016约翰威利父子有限公司
RationaleElectrospray ionization-mass spectrometry (ESI-MS) is an emerging tool for reaction monitoring. It can be accompanied by reaction acceleration in charged droplets.MethodsThe time course of the bulk reaction of indoline-2,3-dione with phenylhydrazine in methanol to produce 3-(2- phenylhydrazono)indolin-2-one was monitored by ESI. Both nanoESI and electrosonic spray ionization (ESSI) were used for this study as representing two common forms of ionization for reaction monitoring. The effect on product yield of the distance the droplets travel between the source and the MS inlet was varied and product/starting material ratios were examined.ResultsProduct yield is dramatically increased by increasing the distance. At short distances reaction monitoring can be performed without acceleration and at greater distances reaction acceleration occurs. This distance effect over the course of the reaction roughly parallels the time dependence of the bulk-phase reaction.ConclusionsReaction acceleration in droplets is attributed to solvent evaporation leading to increased surface to volume ratios. An acceleration factor of 10(4), measured relative to the bulk reaction at short times, is readily achieved by simply increasing the droplet distance of flight showing that the same ionization source can be used to monitor reactions with or without acceleration. Copyright (c) 2016 John Wiley & Sons, Ltd.