The 24-hour rhythm of oxytocin and beta-endorphin secretion in human pregnancy
The 24-hour rhythm of oxytocin and beta-endorphin secretion in human pregnancy
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DOI：
10.1046/j.1365-2265.1996.8290840.x
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发表时间：
1996-10-01
影响因子：
3.2
通讯作者：
vanderSpuy, ZM
中科院分区：
文献类型：
--
作者：
Lindow, SW;Newham, A;vanderSpuy, ZM
目的动物实验表明，母体催产素的分泌受妊娠期内源性阿片类物质分泌的影响。自然分娩和分娩前子宫活动遵循24小时节律，其起源尚未解释，但可能与催产素分泌的昼夜变化有关。这项研究是为了记录产妇催产素和β-内啡肽分泌在24小时内的变化。设计一个4小时的血液剖面进行了24小时的periods.Patients 16名妇女与单胎妊娠超过36周的妊娠和10名妇女与妊娠中期进行了研究。催产素在所有患者和β-内啡肽样免疫反应测定15 patients.Results一个简单的指数定义为比较夜间水平，白天水平的催产素和β-内啡肽。在所有妊娠超过36周的情况下，催产素指数为阳性（夜间水平较高），β-内啡肽指数为阴性（夜间水平较低）。在中期妊娠妇女催产素的指数的所有值都是积极的，但在β-内啡肽组等量表现出积极的或消极的index.CONCLUSIONS相互24小时节律之间表现出催产素和β-内啡肽，但是，目前还不清楚这种关系是否是因果关系。
OBJECTIVE Animal work suggests that maternal oxytocin secretion is influenced by the secretion of endogenous opioids in pregnancy. Spontaneous labour and pre-labour uterine activity follow a 24-hour rhythm the origin of which has not been explained but may be related to diurnal changes in oxytocin secretion. This study was performed to document the changes over a 24-hour period in maternal oxytocin and beta-endorphin secretion.DESIGN A 4-hourly blood profile was undertaken for a 24-hour period.PATIENTS Sixteen women with singleton pregnancies of more than 36 weeks gestation and 10 women with pregnancies in the mid trimester were studied.MEASUREMENTS Blood was sampled 4-hourly for 24 hours beginning at 1200 h. Oxytocin was measured in all patients and beta-endorphin-like immunoreactivity was measured in 15 patients.RESULTS A simple index was defined for comparing night-time levels to daytime levels for both oxytocin and beta-endorphin. In all cases more than 36 weeks gestation the index was positive for oxytocin (night-time levels were higher) and in all cases the index was negative for beta-endorphin (night-time levels were lower). In the mid trimester women ail values of the index for oxytocin were positive but in the beta-endorphin group equal numbers demonstrated a positive or a negative index.CONCLUSIONS Reciprocal 24-hour rhythms were demonstrated between oxytocin and beta-endorphin; however, it is not clear whether this relationship is causal.