Mechanical properties of alginate hydrogels manufactured using external gelation
Mechanical properties of alginate hydrogels manufactured using external gelation
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DOI：
10.1016/j.jmbbm.2014.04.013
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发表时间：
2014-08-01
影响因子：
3.9
通讯作者：
Bowen, James
中科院分区：
文献类型：
--
作者：
Kaklamani, Georgia;Cheneler, David;Bowen, James
藻酸盐水凝胶通常用于生物医学应用中，例如用于组织工程的支架、药物递送以及作为用于细胞固定的介质。多价阳离子通常用于在相邻多糖链上的羧基和羟基部分之间产生物理交联，从而产生具有一系列机械性质的水凝胶。本工作描述了使用二价阳离子Mg 2+、Ca 2+和Sr 2+通过非共价交联促进凝胶化的海藻酸钠水凝胶的制造和表征。甘氨酰时间和杨氏模量的特征在于作为阳离子和藻酸盐浓度的函数。这项工作对使用环境弹性来控制干细胞分化的影响进行了讨论。(C)2014爱思唯尔有限公司版权所有。
Alginate hydrogels are commonly used in biomedical applications such as scaffolds for tissue engineering, drug delivery, and as a medium for cell immobilisation. Multivalent cations are often employed to create physical crosslinks between carboxyl and hydroxyl moieties on neighbouring polysaccharide chains, creating hydrogels with a range of mechanical properties. This work describes the manufacture and characterisation of sodium alginate hydrogels using the divalent cations Mg2+, Ca2+ and Sr2+ to promote gelation via non-covalent crosslinks. Gelation time and Young's modulus are characterised as a function of cation and alginate concentrations. The implications of this work towards the use of environmental elasticity to control stem cell differentiation are discussed. (C) 2014 Elsevier Ltd. All rights reserved.