Pathogenic Role of Immune Cells in Rheumatoid Arthritis: Implications in Clinical Treatment and Biomarker Development.
Pathogenic Role of Immune Cells in Rheumatoid Arthritis: Implications in Clinical Treatment and Biomarker Development.
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作者：
Yap HY;Tee SZ;Wong MM;Chow SK;Peh SC;Teow SY
类风湿性关节炎（RA）是一种慢性、自身免疫性、全身性、炎性疾病，以对称模式影响滑膜关节，包括小关节和大关节。这种疾病通常不会直接导致死亡，但如果不治疗，会显著降低患者的生活质量和预期寿命。RA无法治愈，但患者通常长期服用疾病缓解抗风湿药物（DMARD），以抑制关节炎症，最大限度地减少关节损伤，保护关节功能，并保持疾病缓解。RA与各种免疫细胞密切相关，每种细胞类型对疾病发病机制的贡献不同。免疫细胞分泌的多种免疫调节分子（主要是细胞因子）介导了类风湿关节炎的发病机制，从而使疾病的治疗和管理变得复杂。根据疾病的严重程度，更重要的是，患者对给定药物的反应，有各种治疗RA的方法。RA的早期诊断和（DMARDs）治疗可以显著改善患者的治疗结果。敏感的生物标志物对于疾病的早期检测以及监测疾病的活动和进展至关重要。本文旨在讨论各种免疫细胞和免疫分子在类风湿关节炎中的致病作用。这篇综述还强调了理解免疫细胞在治疗RA和探索新的生物标志物中的重要性。
Rheumatoid arthritis (RA) is a chronic, autoimmune, systemic, inflammatory disorder that affects synovial joints, both small and large joints, in a symmetric pattern. This disorder usually does not directly cause death but significantly reduces the quality of life and life expectancy of patients if left untreated. There is no cure for RA but, patients are usually on long-term disease modifying anti-rheumatic drugs (DMARDs) to suppress the joint inflammation, to minimize joint damage, to preserve joint function, and to keep the disease in remission. RA is strongly associated with various immune cells and each of the cell type contributes differently to the disease pathogenesis. Several types of immunomodulatory molecules mainly cytokines secreted from immune cells mediate pathogenesis of RA, hence complicating the disease treatment and management. There are various treatments for RA depending on the severity of the disease and more importantly, the patient’s response towards the given drugs. Early diagnosis of RA and treatment with (DMARDs) are known to significantly improve the treatment outcome of patients. Sensitive biomarkers are crucial in early detection of disease as well as to monitor the disease activity and progress. This review aims to discuss the pathogenic role of various immune cells and immunological molecules in RA. This review also highlights the importance of understanding the immune cells in treating RA and in exploring novel biomarkers.
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影响因子：
3.7
作者：
Centola M;Cavet G;Shen Y;Ramanujan S;Knowlton N;Swan KA;Turner M;Sutton C;Smith DR;Haney DJ;Chernoff D;Hesterberg LK;Carulli JP;Taylor PC;Shadick NA;Weinblatt ME;Curtis JR
通讯作者：
Curtis JR
滑膜巨噬细胞和巨噬细胞产生的细胞因子在驱动聚集蛋白聚糖酶、基质金属蛋白酶和骨关节炎中其他破坏性和炎症反应中的作用。
影响因子：
4.9
作者：
Bondeson J;Wainwright SD;Lauder S;Amos N;Hughes CE
通讯作者：
Hughes CE
影响因子：
17.1
作者：
Benham, Helen;Nel, Hendrik J.;Thomas, Ranjeny
通讯作者：
Thomas, Ranjeny
影响因子：
4.6
作者：
Chiu YG;Ritchlin CT
通讯作者：
Ritchlin CT
DOI：
10.1186/ar135
发表时间：
2001
期刊：
Arthritis research
影响因子：
--
作者：
Aarvak T;Natvig JB
通讯作者：
Natvig JB