Diosgenin Ameliorates Cognition Deficit and Attenuates Oxidative Damage in Senescent Mice Induced by D-Galactose
Diosgenin Ameliorates Cognition Deficit and Attenuates Oxidative Damage in Senescent Mice Induced by D-Galactose
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DOI：
10.1142/s0192415x11009020
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发表时间：
2011-01-01
影响因子：
5.7
通讯作者：
Peng, Wen-Huang
中科院分区：
文献类型：
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作者：
Chiu, Chuan-Sung;Chiu, Yung-Jia;Peng, Wen-Huang
本研究旨在探讨薯蓣皂苷元对D-半乳糖致衰老小鼠的神经保护作用。实验中的小鼠从第六周开始口服施用薯蓣皂苷元（1、5、25和125 mg/kg），持续四周。采用Morris水迷宫实验观察薯蓣皂苷元对小鼠学习记忆能力的影响，探讨薯蓣皂苷元对小鼠脑组织神经保护作用的机制。与D-gal处理的小鼠（200 mg/kg，10周）相比，在Morris水迷宫测试中显示出显著改善的学习和记忆能力。薯蓣皂苷元还能提高D-半乳糖处理小鼠脑组织超氧化物歧化酶（SOD）和谷胱甘肽过氧化物酶（GSH-Px）的活性，降低丙二醛（MDA）的含量，提示薯蓣皂苷元可能是一种有效的治疗认知障碍的药物。另外，薯蓣皂苷元的记忆增强作用可能部分通过增强内源性抗氧化酶活性来介导。
This study attempted to access the neuroprotective effect of diosgenin on the senescent mice induced by d-galactose (D-gal). The mice in the experiments were orally administered with diosgenin (1, 5, 25 and 125 mg/kg), for four weeks from the sixth week. The learning and memory abilities of the mice in Morris water maze test and the mechanism involved in the neuroprotective effect of diosgenin on the mice brain tissue were investigated.Diosgenin (5, 25 and 125 mg/kg, p.o.) showed significantly improved learning and memory abilities in Morris water maze test compared to D-gal treated mice (200 mg/kg, ten weeks). Diosgenin also increased the activities of superoxide dismutase (SOD) and glutathione peroxidase (GSH-Px), and decreased the malondialdehyde (MDA) level in the brain of D-gal treated mice.These results indicated that diosgenin has the potential to be a useful treatment for cognitive impairment. In addition, the memory enhancing effect of diosgenin may be partly mediated via enhancing endogenous antioxidant enzymatic activities.