Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder
Identification of double-stranded DNA in the cerebrospinal fluid of patients with acute neuromyelitis optica spectrum disorder
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DOI：
10.1016/j.jocn.2022.12.005
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发表时间：
2023-01
影响因子：
2
通讯作者：
Mamoru Yamamoto;T. Okuno;Jin-Lan Piao;Mikito Shimizu;K. Miyamoto;T. Nukui;M. Kinoshita;T. Koda;R. D. Haryuni;H. Mochizuki;T. Sugimoto;Y. Nakatsuji
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文献类型：
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作者：
Mamoru Yamamoto;T. Okuno;Jin-Lan Piao;Mikito Shimizu;K. Miyamoto;T. Nukui;M. Kinoshita;T. Koda;R. D. Haryuni;H. Mochizuki;T. Sugimoto;Y. Nakatsuji
视神经肌萎缩症谱系障碍（NMOSD）是一种以严重肌萎缩和视神经炎为特征的中枢神经系统（CNS）炎症性疾病。双链DNA（dsDNA）参与多种自身免疫性疾病的发病机制，如系统性红斑狼疮。然而，它在NMOSD中的作用仍然不清楚。在这项研究中，在23例NMOSD和16例其他神经系统疾病（OND）患者的脑脊液（CSF）中的dsDNA浓度进行了定量。NMOSD患者的CSF dsDNA水平（中位数：0.03 ng/μL）显著高于OND患者（中位数：0.01 ng/μL）。治疗前后脑脊液dsDNA水平无显著性差异。CSF dsDNA水平的升高可能表明其在NMOSD患者CNS炎症增加中的重要作用。
Neuromyelitis optica spectrum disorder (NMOSD) is an inflammatory disease of the central nervous system (CNS) characterized by severe myelitis and optic neuritis. Double-stranded DNA (dsDNA) is involved in the pathogenesis of various autoimmune diseases, such as systemic lupus erythematosus. However, its role in NMOSD remains unclear. In this study, the concentration of dsDNA in the cerebrospinal fluid (CSF) was quantified in 23 patients with NMOSD and 16 patients with other neurological diseases (ONDs). CSF dsDNA levels in patients with NMOSD (median: 0.03 ng/µL) were significantly higher than those in patients with ONDs (median: 0.01 ng/μl). CSF dsDNA levels showed no significant difference before and after treatment. Elevation of CSF dsDNA levels may suggest its essential role in the augmentation of CNS inflammation in patients with NMOSD.