Connected to death: The (unexpurgated) mitochondrial pathway of apoptosis
Connected to death: The (unexpurgated) mitochondrial pathway of apoptosis
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DOI：
10.1126/science.1117105
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发表时间：
2005-10-07
期刊：
影响因子：
56.9
通讯作者：
Green, DR
中科院分区：
文献类型：
--
作者：
Spierings, D;McStay, G;Green, DR
脊椎动物的线粒体凋亡途径依赖于线粒体外膜透化（MOMP）过程，其导致蛋白质从线粒体膜间隙释放到胞质溶胶中。这个事件的“上层”是调节和介导MOMP的Bcl-2家族蛋白;“下层”是协调细胞解体的半胱天冬酶的激活。在科学的信号转导知识环境（STKE）的连接图数据库中，说明了定义细胞凋亡线粒体途径的途径，并进行了大量的控制。MOMP的“楼上”
The mitochondrial pathway of apoptosis in vertebrates is dependent on the process of mitochondrial outer membrane permeabilization (MOMP), which leads to the release of proteins from the mitochondrial intermembrane space into the cytosol. "Upstairs" of this event are the Bcl-2 family proteins that regulate and mediate MOMP; "downstairs" is the activation of caspases that orchestrate the dismantling of the cell. In the Connections Map database at Science's Signal Transduction Knowledge Environment (STKE), the pathways that define the mitochondrial pathway of apotosis are illustrated, with the bulk of control occurring. "upstairs" of MOMP.