Effects of smoking cessation on lung function and airway inflammation in smokers with asthma
Effects of smoking cessation on lung function and airway inflammation in smokers with asthma
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DOI：
10.1164/rccm.200510-1589oc
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发表时间：
2006-07-15
影响因子：
24.7
通讯作者：
Thomson, Neil C.
中科院分区：
文献类型：
--
作者：
Chaudhuri, Rekha;Livingston, Eric;Thomson, Neil C.
基本原理：主动吸烟与哮喘症状恶化，肺功能加速下降，皮质类固醇反应受损。Objectives：To examine the short-term effects of smoking cases within smokers with asthma.Methods and Measurements：Smokers with asthma were given the option to quit or continue smoking.两组均在基线和第1、3和6周进行肺功能测定和诱导痰。皮肤血管收缩反应局部倍氯米松气道反应口服泼尼松龙，外周血淋巴细胞对皮质类固醇的敏感性进行了测定戒烟前和6 wk.Main结果：招募的32例，11选择继续吸烟（吸烟对照组）。选择戒烟的21例受试者中，10例戒烟6 wk（戒烟组）。戒烟者与吸烟者6周时FEV 1的平均差异（置信区间[CI]）为407 ml（21，793），p = 0.040，痰中性粒细胞比例降低29（51，8），p = 0.039。戒烟后局部用倍氯米松的总皮肤血管收缩反应评分改善，戒烟者和吸烟者之间的平均（CI）差异为3.56（0.84，6.28），p = 0.042。有没有变化，在气道皮质类固醇反应后戒烟。结论：6周后戒烟，戒烟的受试者取得了相当大的改善肺功能和痰中性粒细胞计数下降相比，受试者谁继续吸烟。这些发现强调了戒烟对哮喘的重要性。
Rationale: Active smoking in asthma is associated with worsening of symptoms, accelerated decline in lung function, and impaired response to corticosteroids.Objectives: To examine the short-term effects of smoking cessation on lung function, airway inflammation, and corticosteroid responsiveness in smokers with asthma.Methods and Measurements: Smokers with asthma were given the option to quit or continue smoking. Both groups underwent spirometry and induced sputum at baseline and at 1, 3, and 6 wk. Cutaneous vasoconstrictor response to topical beclometasone airway response to oral prednisolone, and sensitivity of peripheral blood lymphocytes to corticosteroids were measured before smoking cessation and at 6 wk.Main Results: Of 32 subjects recruited, 11 opted to continue smoking (smoking control group). Of 21 subjects who opted for smoking cessation, 10 quit smoking for 6 wk (quit group). In the comparison of quitters with smokers at 6 wk, the mean (confidence interval [Cl]) difference in FEV1 was 407 ml (21, 793), p = 0.040, and the proportion of sputum neutrophils was reduced by 29 (51, 8), p = 0.039. Total cutaneous vasoconstrictor response score to topical beclometasone improved after smoking cessation with a mean (CI) difference of 3.56 (0.84, 6.28), p = 0.042, between quitters and smokers. There was no change in airway corticosteroid responses after smoking cessation.Conclusions: By 6 wk after smoking cessation, subjects who quit smoking had achieved considerable improvement in lung function and a fall in sputum neutrophil count compared with subjects who continued to smoke. These findings highlight the importance of smoking cessation in asthma.