Nutritional factors and osteoarthritis: recent developments
Nutritional factors and osteoarthritis: recent developments
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营养因素和骨关节炎：最新进展
DOI：
10.1097/01.bor.0000175461.57749.46
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发表时间：
2005
影响因子：
5.1
通讯作者：
B. A. Biggee
中科院分区：
文献类型：
--
作者：
T. McAlindon;B. A. Biggee
综述的目的营养和营养补充剂在骨性关节炎的发展和进展中的作用现在是一个公众、工业界和学术界都很感兴趣的话题。这篇综述着重于最近的研究如何改变了营养因素或营养补充剂在膝骨性关节炎治疗中的作用的证据。最近的研究包括作为膝关节骨关节炎干预措施的减肥和运动的临床试验，对软骨细胞基因组氧化应激机制的阐明，对自发性骨关节炎动物补充维生素C的进一步研究，以及进一步的氨基葡萄糖和硫酸软骨素的临床和药效学评估。这些研究中令人困惑的发现包括维生素C对Hartley豚鼠骨关节炎的有害影响，口服剂量后血清中氨基葡萄糖的低水平，最近氨基葡萄糖的阴性临床研究，以及氨基葡萄糖试验结果的异质性。摘要随着这一领域研究的深入，出现了新的临床和基础科学数据，有时会产生令人惊讶的结果。这些研究证实了营养干预在骨性关节炎中发挥作用的相当大的潜力，但它们强调了对此类产品的声称进行系统科学评估的必要性。
Purpose of reviewThe role of nutrition and nutritional supplements in the development and progression of osteoarthritis is now a topic of considerable public, industry, and academic interest. This review focuses on how the evidence for a role of nutritional factors or nutritional supplements in the management of knee osteoarthritis has been changed by recent research. Recent findingsRecent studies include clinical trials of weight loss and exercise as interventions for osteoarthritis of the knee, the elucidation of mechanisms of oxidative stress on the chondrocyte genome, further study of vitamin C supplementation in an animal with spontaneous osteoarthritis, and further clinical and pharmacodynamic evaluations of glucosamine and chondroitin sulfate. Perplexing findings among these studies include the deleterious effects of vitamin C on osteoarthritis in the Hartley guinea pig, the low levels of glucosamine achieved in serum after an oral dose, recent negative clinical studies of glucosamine, and the heterogeneity of results among glucosamine trials. SummaryWith an intensification of research in this field come new clinical and basic science data, sometimes with surprising results. These confirm the considerable potential for a role of nutritional interventions for osteoarthritis, but they emphasize the need for systematic scientific evaluation of the claims made for such products.
影响因子：
--
作者：
Messier, SP;Loeser, RF;Williamson, J
通讯作者：
Williamson, J