EFFECTS ON VISUAL RECOGNITION OF COMBINED AND SEPARATE ABLATIONS OF THE ENTORHINAL AND PERIRHINAL CORTEX IN RHESUS-MONKEYS
EFFECTS ON VISUAL RECOGNITION OF COMBINED AND SEPARATE ABLATIONS OF THE ENTORHINAL AND PERIRHINAL CORTEX IN RHESUS-MONKEYS
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DOI：
10.1523/jneurosci.13-12-05418.1993
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发表时间：
1993-12-01
影响因子：
5.3
通讯作者：
MURRAY, EA
中科院分区：
文献类型：
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作者：
MEUNIER, M;BACHEVALIER, J;MURRAY, EA
在联合和单独消融嗅周和内嗅皮质的恒河猴以及未手术对照组中评估视觉延迟非匹配样本的性能。组合（即，鼻皮质）损伤后，在这项任务上产生了显著的损害，其严重程度几乎与杏仁核海马体联合切除（包括一些下丘脑皮质）后所见的损害一样（Mishkin，1978; Murray and Mishkin，1984）。单独切除嗅周皮质产生的赤字几乎一样严重，发现后鼻皮质病变，而单独切除内嗅皮质只产生轻微的赤字。与早期研究（Murray和Mishkin，1986）的结论相反，目前的结果表明，不仅限于鼻皮质的损伤足以造成视觉识别的严重损失，而且这种损伤导致的损失远远大于颞叶内侧部分任何其他单一结构的损伤。
Performance on visual delayed nonmatching-to-sample was assessed in rhesus monkeys with combined and separate ablations of the perirhinal and entorhinal cortex, as well as in unoperated controls. Combined (i.e., rhinal cortex) lesions yielded a striking impairment on this task, one almost as severe as that seen after combined amygdalohippocampal removals that included some of this subjacent cortex (Mishkin, 1978; Murray and Mishkin, 1984). Ablations of the perirhinal cortex alone produced a deficit nearly as severe as that found after rhinal cortex lesions, whereas ablations of the entorhinal cortex alone produced only a mild deficit. Contrary to the conclusion from an earlier study (Murray and Mishkin, 1 986), the present results demonstrate not only that damage limited to the rhinal cortex is sufficient to produce a severe loss in visual recognition, but also that such damage leads to a far greater loss than damage to any other single structure in the medial part of the tem oral lobe.