Disrupted white matter integrity in depressed versus non-depressed Parkinson's disease patients: A tract-based spatial statistics study
Disrupted white matter integrity in depressed versus non-depressed Parkinson's disease patients: A tract-based spatial statistics study
复制标题
抑郁症与非抑郁症帕金森病患者的白质完整性受损：基于束的空间统计研究
DOI：
10.1016/j.jns.2014.08.011
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发表时间：
2014-11-15
影响因子：
4.4
通讯作者：
Zhang, Minming
中科院分区：
文献类型：
--
作者：
Huang, Peiyu;Xu, Xiaojun;Zhang, Minming
抑郁是帕金森病（PD）患者的常见症状，但其病理生理机制尚不清楚。随着越来越多的证据表明抑郁症是一种断开综合征，我们假设PD中的抑郁症是由大脑中的纤维连接退化引起的。我们检查了15例抑郁症PD患者和15例非抑郁症PD患者的全脑白色物质完整性。采用统一帕金森病评定量表、汉密尔顿抑郁量表和简易精神状态检查量表对所有患者进行评定。计算两组间的白色物质差异及其与病情严重程度的相关性。在抑郁的PD患者中，在左侧钩束、上级纵束、丘脑前放射、小钳和下纵束中发现了分数各向异性降低。左颞叶皮层各向异性分数与抑郁严重程度呈负相关（r =-0.671，p = 0.034）。我们的研究结果表明，在左半球的前部中断的纤维连接可能有助于抑郁症患者。(C)2014爱思唯尔有限公司版权所有。
Depression is a common occurrence in patients with Parkinson's disease (PD), however, its pathophysiology still remains unclear. With increasing evidence suggesting that depression is a disconnection syndrome, we hypothesized that depression in PD is caused by degenerated fiber connections in the brain. We examined whole brain white matter integrity in 15 depressed PD patients and 15 non-depressed PD patients. All the patients were assessed with the Unified Parkinson's Disease Rating Scale, the Hamilton Rating Scale for Depression, and the Mini-Mental State Examination. White matter difference between the two groups and its correlation with disease severity was calculated. In depressed PD patients, decreased fractional anisotropy was found in the left uncinate fasciculus, superior longitudinal fasciculus, anterior thalamic radiation, forceps minor, and the inferior longitudinal fasciculus. Fractional anisotropy in the left deep temporal cortex was negatively correlated with severity of depression (r = -0.671, p = 0.034). Our results suggest that disrupted fiber connections in the anterior part of the left hemisphere may contribute to depression in PD patients. (C) 2014 Elsevier B.V. All rights reserved.