Human immunodeficiency virus superinfection and recombination: Current state of knowledge and potential clinical consequences
Human immunodeficiency virus superinfection and recombination: Current state of knowledge and potential clinical consequences
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DOI：
10.1086/339547
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发表时间：
2002-04-15
影响因子：
11.8
通讯作者：
Mayer, KH
中科院分区：
文献类型：
--
作者：
Blackard, JT;Cohen, DE;Mayer, KH
人类和猿类免疫缺陷病毒的多种毒株或亚型的重叠感染已被记录在案。最近，无保护措施的肛交和性传播疾病在男男性行为中的流行率上升，这表明这些男性继续进行不安全的性行为，因此面临感染人类免疫缺陷病毒(艾滋病毒)的风险。从事高危行为的血清阳性者反复接触艾滋病毒可能会产生严重的后果，因为重叠感染是病毒重组发生的必要的第一步。重组可能产生更强的病毒、抗药性病毒或细胞嗜性改变的病毒。此外，重组病毒和重叠感染可加速疾病进展，并通过增加血液和生殖道中的病毒载量而增加性传播的可能性。艾滋病毒携带者重叠感染和重组的程度尚不清楚。讨论了HIV重叠感染和重组病毒的产生的意义。
Superinfection with multiple strains or subtypes of the human and simian immunodeficiency viruses has been documented. Recent increases in the prevalences of both unprotected anal intercourse and sexually transmitted diseases among men who have sex with men indicate that these men continue to practice unsafe sex and, therefore, are at risk for superinfection with the human immunodeficiency virus (HIV). Recurrent exposure to HIV among seropositive individuals who engage in high-risk behaviors can have serious consequences, because superinfection is a necessary first step for viral recombination to occur. Recombination may produce more virulent viruses, drug-resistant viruses, or viruses with altered cell tropism. Additionally, recombinant viruses and superinfection can accelerate disease progression and increase the likelihood of sexual transmission by increasing virus load in the blood and genital tract. The extent of superinfection and recombination in persons living with HIV is unknown. The implications of HIV superinfection and the generation of recombinant viruses are discussed.