Renal vascular structure and rarefaction.
Renal vascular structure and rarefaction.
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DOI：
10.1002/cphy.c120012
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发表时间：
2013-04
影响因子：
5.8
通讯作者：
Chade AR
中科院分区：
文献类型：
--
作者：
Chade AR
完整的微循环对于氧气和营养物质的扩散以及人体每个器官和系统的毒素清除至关重要。微血管的功能和/或解剖学损失被称为稀疏，其可以损害正常器官功能，并且已经被认为是几种疾病的可能起点。本综述的目的是讨论导致肾微血管稀疏的潜在机制，以及对肾功能和肾损害进展的潜在后果。虽然肾脏是一个特殊的器官，接收的血液远远超过其代谢的需要，实验和临床证据表明，肾微血管稀疏与流行的心血管疾病，如糖尿病，高血压和动脉粥样硬化，无论是原因或后果。另一方面，使用祖细胞或血管生成细胞因子的新兴实验证据支持能够改变肾脏中微血管稀疏的进行性性质的治疗干预的可行性。本综述还将试图讨论肾微循环治疗靶向的潜在肾脏保护机制。
An intact microcirculation is vital for diffusion of oxygen and nutrients and for removal of toxins of every organ and system in the human body. The functional and/or anatomical loss of microvessels is known as rarefaction, which can compromise the normal organ function and have been suggested as a possible starting point of several diseases. The purpose of this overview is to discuss the potential underlying mechanisms leading to renal microvascular rarefaction, and the potential consequences on renal function and on the progression of renal damage. Although the kidney is a special organ that receives much more blood than its metabolic needs, experimental and clinical evidence indicates that renal microvascular rarefaction is associated to prevalent cardiovascular diseases such as diabetes, hypertension, and atherosclerosis, either as cause or consequence. On the other hand, emerging experimental evidence using progenitor cells or angiogenic cytokines supports the feasibility of therapeutic interventions capable of modifying the progressive nature of microvascular rarefaction in the kidney. This overview will also attempt to discuss the potential renoprotective mechanisms of the therapeutic targeting of the renal microcirculation.
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影响因子：
13.6
作者：
Chade, Alejandro R.;Krier, James D.;Lerman, Lilach O.
通讯作者：
Lerman, Lilach O.
DOI：
10.1152/ajprenal.00385.2003
发表时间：
2004-06-01
影响因子：
4.2
作者：
Chade, AR;Krier, JD;Lerman, LO
通讯作者：
Lerman, LO
影响因子：
20.1
作者：
Bakker, ENTP;Buus, CL;VanBavel, E
通讯作者：
VanBavel, E
影响因子：
2.4
作者：
Benest, Andrew V.;Salmon, Andrew H.;Bates, David O.
通讯作者：
Bates, David O.
DOI：
10.1046/j.1365-2362.2003.01091.x
发表时间：
2003-01-01
影响因子：
5.5
作者：
Bax, L;van der Graaf, Y;Mali, WPTM
通讯作者：
Mali, WPTM