DIFFERENTIAL ADDITION OF CELLS TO RETINA IN RANA PIPIENS TADPOLES
DIFFERENTIAL ADDITION OF CELLS TO RETINA IN RANA PIPIENS TADPOLES
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DOI：
10.1016/0012-1606(68)90041-9
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发表时间：
1968-01-01
影响因子：
2.7
通讯作者：
HOLLYFIELD, JG
中科院分区：
文献类型：
--
作者：
HOLLYFIELD, JG
在豚鼠中，视网膜内核层的细胞数量不断增加。在第一阶段，这一层只有两个细胞厚。在第二十五期蜕变结束时，这一层的厚度已达到10-11个细胞的深度。秋水仙碱和胸腺嘧啶- 3h测定添加到该层的新细胞的来源和分布方式。视网膜边缘有丝分裂产生新细胞。这是秋水仙碱长期治疗后观察到有丝分裂的唯一区域。视网膜边缘的细胞核在分裂前很容易与胸腺嘧啶- 3h结合。有丝分裂后，标记的细胞进入内核层并向眼底区域迁移。他们的移动速度在离开边缘后的几天里稳步下降。当动物准备离开水，从海底杂食动物转变为贪婪的食肉动物时，这些新细胞可能负责视觉系统需求的变化。
InRana pipienstadpoles the number of cells in the inner nuclear layer of the retina continuously increases. At stage I this layer is only two cells thick. By the end of metamorphosis at stage XXV the thickness of this layer has reached a level of 10–11 cells in depth.Colchicine and thymidine-3H were used to determine the source and manner of distribution of the new cells added to this layer.New cells are produced by mitosis at the margin of the retina. This is the only region where mitotic figures are observed following colchicine treatment for extended periods.Nuclei at the margin of the retina readily incorporate thymidine-3H prior to division. Following mitosis, labeled cells move into the inner nuclear layer and migrate toward the fundic region of the eye. The velocity of their movement steadily decreases on subsequent days following emigration from the margin.These new cells may be responsible for the change in the requirements of the visual system as the animal prepares to leave the water and change from a bottom feeding omnivore to a voracious carnivore.