Could respiration-driven blood oxygen changes modulate neural activity?
Could respiration-driven blood oxygen changes modulate neural activity?
复制标题
呼吸驱动的血氧变化能否调节神经活动？
DOI：
10.1007/s00424-022-02721-8
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Drew,PatrickJ
中科院分区：
文献类型：
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作者：
Zhang,Qingguang;Haselden,WilliamD;Charpak,Serge;Drew,PatrickJ
氧气对神经代谢至关重要，但在大多数生理条件下，大脑中的氧气水平远远超过所需。氧气水平可以通过呼吸率的增加而动态增加，呼吸率与大脑和认知的唤醒状态有关，而不一定与身体的运动有关。为什么这些呼吸变化发生在氧气已经足够的时候，这是一个长期存在的谜团。在人类中，认知任务的表现可能会受到非常高或非常低的氧气水平的影响，但呼吸产生的血氧生理变化是否有明显的影响是一个悬而未决的问题。氧对钾通道有直接作用，增加一氧化氮的降解速率，并限制某些神经调质的合成速率。我们讨论是否氧合变化，由于呼吸有助于神经动力学与注意力和觉醒。
Oxygen is critical for neural metabolism, but under most physiological conditions, oxygen levels in the brain are far more than are required. Oxygen levels can be dynamically increased by increases in respiration rate that are tied to the arousal state of the brain and cognition, and not necessarily linked to exertion by the body. Why these changes in respiration occur when oxygen is already adequate has been a long-standing puzzle. In humans, performance on cognitive tasks can be affected by very high or very low oxygen levels, but whether the physiological changes in blood oxygenation produced by respiration have an appreciable effect is an open question. Oxygen has direct effects on potassium channels, increases the degradation rate of nitric oxide, and is rate limiting for the synthesis of some neuromodulators. We discuss whether oxygenation changes due to respiration contribute to neural dynamics associated with attention and arousal.