Real-time monitoring of controllable cavitation erosion in a vessel phantom with passive acoustic mapping
Real-time monitoring of controllable cavitation erosion in a vessel phantom with passive acoustic mapping
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利用被动声学测绘实时监测容器模型中的可控空化侵蚀
DOI：
10.1016/j.ultsonch.2017.03.060
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发表时间：
2017
影响因子：
8.4
通讯作者：
Wan Mingxi
中科院分区：
文献类型：
--
作者：
Lu Shukuan;Shi Aiwei;Jing Bowen;Du Xuan;Wan Mingxi
血管中的空泡侵蚀在超声溶栓、药物输送等临床应用中起着重要作用。利用基于超声驻波的可控性浅表血管腐蚀技术，有效地预防血管破裂出血，并采用光学方法进行了实验观察。但光学方法只能在透明介质中工作。与标准B超成像相比，被动声标测（PAM）能真实的实时监测腐蚀，对空化检测具有更高的灵敏度。然而，常规使用的PAM在成像分辨率和伪影方面具有限制。在这项研究中，提出了一种独特的PAM方法，将鲁棒的Capon波束形成器（RCB）与符号相干因子（SCF）相结合，以真实的实时监测表浅血管侵蚀。实验结果表明，所提出的PAM的横向（轴向）分辨力为2.31 ± 0.51比基于时间暴露声学（TEA）的PAM高（3.19 ± 0.38）倍，（1.76 ± 0.48）倍，空化伪影比（CAR）分别比TEA和RCB PAM提高了22.5 ± 3.2 dB和7.1 ± 1.2 dB。这些结果表明，所提出的PAM可以精确地监测浅表血管侵蚀和USW调制后的侵蚀移位。这项工作可能有潜力开发一个有用的工具，精确的空间控制和实时监测的浅表血管侵蚀。
Cavitation erosion in blood vessel plays an important role in ultrasound thrombolysis, drug delivery, and other clinical applications. The controllable superficial vessel erosion based on ultrasonic standing wave (USW) has been used to effectively prevent vessel ruptures and haemorrhages, and optical method is used to observe the experiments. But optical method can only work in transparent media. Compared with standard B-mode imaging, passive acoustic mapping (PAM) can monitor erosion in real time and has better sensitivity of cavitation detection. However, the conventionally used PAM has limitations in imaging resolution and artifacts. In this study, a unique PAM method that combined the robust Capon beamformer (RCB) with the sign coherence factor (SCF) was proposed to monitor the superficial vessel erosion in real time. The performance of the proposed method was validated by simulations.In vitroexperiments showed that the lateral (axial) resolution of the proposed PAM was 2.31 ± 0.51 (3.19 ± 0.38) times higher than time exposure acoustics (TEA)-based PAM and 1.73 ± 0.38 (1.76 ± 0.48) times higher than RCB-based PAM, and the cavitation-to-artifact ratio (CAR) of the proposed PAM could be improved by 22.5 ± 3.2 dB and 7.1 ± 1.2 dB compared with TEA and RCB-based PAM. These results showed that the proposed PAM can precisely monitor the superficial vessel erosion and the erosion shift after USW modulation. This work may have the potential of developing a useful tool for precise spatial control and real-time monitoring of the superficial vessel erosion.