Regulation of Airway Innate and Adaptive Immune Responses: The IL-17 Paradigm
Regulation of Airway Innate and Adaptive Immune Responses: The IL-17 Paradigm
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DOI：
10.1615/critrevimmunol.v28.i4.10
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发表时间：
2008-01-01
影响因子：
1.3
通讯作者：
Wu, Reen
中科院分区：
文献类型：
--
作者：
Hung, Li-Yin;Velichko, Sharlene;Wu, Reen
IL-17是由免疫细胞产生的促炎细胞因子。其在宿主防御和疾病发展中的重要性已在各种感染和自身免疫模型中得到证实。最近，另外的研究表明IL-17在几个方面也在调节气道免疫应答中是重要的。沿着完善的Th 1/Th 2模型，关于Th 17谱系和IL-17功能的新发现为已经复杂的调节气道免疫的细胞因子网络增加了额外的扭曲。IL-17受体在血细胞上以及在结构细胞如气道中的上皮细胞上表达。因此，IL-17对气道免疫的影响非常广泛，涵盖先天性和适应性两个方面。本文就近年来IL-17在肺免疫应答中的信号转导和功能以及IL-17在疾病发病机制中的作用作一综述。
IL-17 is a proinflammatory cytokine produced by immune cells. Its significance in host defense and disease development has been demonstrated in various infection and autoimmune models. Recently, additional studies have shown that IL-17 is also important in modulating airway immune response in several aspects. Along with the well-established Th1/Th2 model, new discoveries regarding the Th17 lineage and IL-17 functions have added an extra twist to the already complicated cytokine network that regulates airway immunity. The IL-17 receptor is expressed on blood cells, as well as on structural cells such as the epithelial cells in the airway. Therefore, the effect of IL-17 on airway immunity is very broad, covering both the innate and the adaptive aspects. In this review, we summarize the findings of recent studies on IL-17 signaling and function in pulmonary immune response, and the implications of IL-17 in disease pathogenesis.