14-3-3 Proteins: diverse functions in cell proliferation and cancer progression.
14-3-3 Proteins: diverse functions in cell proliferation and cancer progression.
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DOI：
10.1016/j.semcdb.2011.08.009
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发表时间：
2011-09
影响因子：
7.3
通讯作者：
Morrison, Deborah K.
中科院分区：
文献类型：
--
作者：
Freeman, Alyson K.;Morrison, Deborah K.
14-3-3蛋白是第一个被发现的磷丝氨酸/磷苏氨酸结合蛋白，这一发现为它们在细胞信号传导中的重要作用提供了基础。14-3-3家族成员与多种蛋白质相互作用，包括转录因子、生物合成酶、细胞骨架蛋白、信号分子、凋亡因子和肿瘤抑制因子。与14-3-3的相互作用可以对靶蛋白产生深远的影响，改变其定位、稳定性、构象、磷酸化状态、活性和/或分子相互作用。因此，通过调节多种结合伙伴的功能，14-3-3蛋白已成为许多重要细胞过程的关键调节成分，这些过程对正常生长和发育至关重要，但在人类癌症中经常出现失调。本文将进一步研究14-3-3蛋白在正常生长和癌症信号传导中的作用，重点关注影响细胞增殖、细胞迁移和上皮-间质转化的信号通路。
The 14-3-3 proteins were the first phosphoserine/phosphothreonine-binding proteins to be discovered, a finding that provided the foundation for their prominent role in cell signaling. 14-3-3 family members interact with a wide spectrum of proteins including transcription factors, biosynthetic enzymes, cytoskeletal proteins, signaling molecules, apoptosis factors, and tumor suppressors. The interaction with 14-3-3 can have a profound effect on a target protein, altering its localization, stability, conformation, phosphorylation state, activity, and/or molecular interactions. Thus, by modulating the function of a diverse array of binding partners, 14-3-3 proteins have become key regulatory components in many vital cellular processes – processes that are crucial for normal growth and development and that often become dysregulated in human cancer. This review will examine the recent advances that further elucidate the role of 14-3-3 proteins in normal growth and cancer signaling with a particular emphasis on the signaling pathways that impact cell proliferation, cell migration, and epithelial-to-mesenchymal transition.
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DOI：
10.1083/jcb.201009069
发表时间：
2011-05-16
期刊：
The Journal of cell biology
影响因子：
--
作者：
Habbig S;Bartram MP;Müller RU;Schwarz R;Andriopoulos N;Chen S;Sägmüller JG;Hoehne M;Burst V;Liebau MC;Reinhardt HC;Benzing T;Schermer B
通讯作者：
Schermer B
影响因子：
21.3
作者：
Eiseler T;Döppler H;Yan IK;Kitatani K;Mizuno K;Storz P
通讯作者：
Storz P
影响因子：
16
作者：
Andrianantoandro, Ernesto;Pollard, Thomas D.
通讯作者：
Pollard, Thomas D.
DOI：
10.1073/pnas.0605266104
发表时间：
2007-01-30
影响因子：
11.1
作者：
Hossain, Zakir;Ali, Safiah Mohamed;Hunziker, Walter
通讯作者：
Hunziker, Walter
影响因子：
50.3
作者：
Lu J;Guo H;Treekitkarnmongkol W;Li P;Zhang J;Shi B;Ling C;Zhou X;Chen T;Chiao PJ;Feng X;Seewaldt VL;Muller WJ;Sahin A;Hung MC;Yu D
通讯作者：
Yu D