Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis
Lipid peroxidation levels and total oxidant status in serum, saliva and gingival crevicular fluid in patients with chronic periodontitis
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DOI：
10.1111/j.1600-051x.2007.01091.x
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发表时间：
2007-07-01
影响因子：
6.7
通讯作者：
Karabulut, Erdem
中科院分区：
文献类型：
--
作者：
Akalin, Ferda Alev;Baltacioglu, Esra;Karabulut, Erdem
目的：活性氧水平的增加导致氧化应激。最近的数据表明，增加脂质过氧化（LPO）水平和氧化应激牙周炎。丙二醛（MDA），一个重要的LPO产品，增加在氧化应激。本研究通过对36例慢性牙周炎（CP）患者和28例牙周健康者的血清、唾液和龈沟液（GCF）中丙二醛（MDA）含量和总氧化状态（TOS）的测定，探讨了CP患者血清、唾液和GCF中MDA含量和TOS的变化规律。结果：CP组唾液和龈沟液中MDA含量及血清、唾液和龈沟液中TOS含量均显著高于对照组（p < 0.05），而血清MDA含量无显著性差异（p > 0.05）。结论：牙周炎患者牙周袋/口腔环境中LPO水平局部升高，而牙周炎患者牙周组织中TOS水平局部和全身均升高。结果提示，LPO和TOS的升高可能在牙周炎的病理过程中起重要作用，并与牙周临床状况密切相关。
Objectives: Increased levels of reactive oxygen species lead to oxidative stress. Recent data suggest increased lipid peroxidation (LPO) levels and oxidative stress in periodontitis. Malondialdehyde (MDA), a significant LPO product, increases in oxidative stress. In this study, MDA levels and total oxidant status (TOS) in serum, saliva and gingival crevicular fluid (GCF) were investigated in patients with chronic periodontitis (CP).Materials and Methods: Thirty-six CP patients and 28 periodontally healthy controls were included in the study. Following clinical measurements and samplings, MDA and TOS levels were measured by high-performance liquid chromatography and a novel automatic colorimetric method, respectively.Results: While the saliva and GCF MDA levels, and serum, saliva and GCF TOS values were significantly higher in the CP group than the control group (p < 0.05), no significant difference in serum MDA levels was found (p > 0.05). Strong positive correlations were observed between periodontal parameters and MDA and TOS levels (p < 0.05).Conclusions: The results revealed that LPO significantly increased locally in the periodontal pocket/oral environment, while TOS displayed both systemic and local increases in periodontitis. The findings suggest that increased LPO and TOS may play an important role in the pathology of periodontitis, and are closely related to the clinical periodontal status.