Histone deacetylases govern cellular mechanisms underlying behavioral and synaptic plasticity in the developing and adult brain.
Histone deacetylases govern cellular mechanisms underlying behavioral and synaptic plasticity in the developing and adult brain.
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DOI：
10.1097/fbp.0b013e32833c20c0
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发表时间：
2010-09
影响因子：
1.6
通讯作者：
Monteggia LM
中科院分区：
文献类型：
--
作者：
Morris MJ;Karra AS;Monteggia LM
组蛋白脱乙酰酶（HDAC）是通过修饰染色质结构来改变基因表达模式的酶家族。有11种哺乳动物HDAC通过同源性分为四个亚家族，它们在脑中都具有不同的表达模式。通过使用药理学HDAC抑制剂，以及最近的HDAC敲除小鼠，这些酶在中枢神经系统中的作用开始被阐明。我们将讨论关于个体HDAC在大脑中的特定或冗余作用的最新发现，以及HDAC功能对复杂行为的影响，重点是学习，记忆形成和情感行为。潜在的HDAC介导的细胞机制，这些行为进行了讨论。
Histone deacetylases (HDACs) are a family of enzymes that alter gene expression patterns by modifying chromatin architecture. There are 11 mammalian HDACs that are classified by homology into four subfamilies, all with distinct expression patterns in brain. Through the use of pharmacological HDAC inhibitors, and more recently HDAC knockout mice, the role of these enzymes in the central nervous system are starting to be elucidated. We will discuss the latest findings on the specific or redundant roles of individual HDACs in brain as well as the impact of HDAC function on complex behavior, with a focus on learning, memory formation, and affective behavior. Potential HDAC-mediated cellular mechanisms underlying those behaviors are discussed.