Lessons learned from randomizing infants to marine oil-supplemented formulas in nutrition trials.
Lessons learned from randomizing infants to marine oil-supplemented formulas in nutrition trials.
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在营养试验中将婴儿随机分配到添加海洋油的配方奶粉中吸取的经验教训。
DOI：
10.1016/s0022-3476(06)80734-1
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发表时间：
1994
期刊：
影响因子：
--
通讯作者：
Carlson,SE
中科院分区：
文献类型：
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作者：
Carlson,SE
已在随机分配至二十二碳六烯酸海洋油源或标准婴儿配方食品的婴儿中评估了n-3脂肪酸摄入对二十二碳六烯酸（22：6 n-3）和花生四烯酸（20：4 n-6）状态、生长、视网膜生理学、视力和发育（Bayley智力发育指数和Fagan Infantest）的影响。本文将重点介绍在进行这些随机试验的经验教训，有关设计，实施和解释的问题。通过解决这些问题，我们希望可以探讨与婴儿营养研究相关的几个一般概念，这些概念可能对其他进行临床营养试验的人有用，特别是n-3和n-6脂肪酸试验。
The effect of n-3 fatty acid intake on docosahexaenoic acid (22:6n-3) and arachidonic acid (20:4n-6)) status, growth, retinal physiology, visual acuity, and development (Bayley Mental Developmental Index and Fagan Infantest) has been evaluated in infants randomized to a marine oil source of docosa hexaenoic acid or to standard infant formula. This article will focus on the lessons learned in conducting these randomized trials—issues related to design, implementation, and interpretation. By addressing these issues it is hoped that several general concepts related to nutrition studies in infants can be explored that might prove useful to others who undertake clinical nutrition trials in general, and trials with n-3 and n-6 fatty acids in particular.