The investigation of serum vaspin level in atherosclerotic coronary artery disease.
The investigation of serum vaspin level in atherosclerotic coronary artery disease.
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DOI：
10.4021/jocmr841w
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发表时间：
2012-04
期刊：
影响因子：
--
通讯作者：
Ilhan S
中科院分区：
文献类型：
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作者：
Kobat MA;Celik A;Balin M;Altas Y;Baydas A;Bulut M;Aydin S;Dagli N;Yavuzkir MF;Ilhan S
推测脂肪组织来源的脂肪细胞因子可能在动脉粥样硬化的发病机制中起一定作用。这些脂肪细胞因子可通过影响内皮细胞、动脉平滑肌细胞和巨噬细胞来改变血管内稳态。Vaspin是新近发现的脂肪细胞因子家族成员。我们的目的是研究血浆vaspin水平是否对冠状动脉疾病（CAD）有任何预测价值。40例经血管造影证实至少有一条血管狭窄≥ 70%的患者和40例冠状动脉解剖结构正常的受试者被纳入本研究。通过ELISA方法从通过离心血液获得并储存在-20 ° C的血清中测量vaspin水平。测量患者的身长、体重和体重指数。同时检测血清总胆固醇、低密度脂蛋白、高密度脂蛋白、肌酐、钠、钾、血红素、尿酸和空腹血糖等生化指标。两组的生化标志物水平相似。冠心病组血清vaspin水平（256 ± 219 pg/ml）明显低于对照组（472 ± 564 pg/ml）（P < 0.02）。此外，高收缩压对照组血清vaspin水平较低。发现CAD患者的血清vaspin水平显著低于年龄匹配的冠状动脉解剖正常的受试者。Vaspin可用作CAD的预测因子。冠状动脉疾病; Vaspin;脂肪因子
It was speculated that fatty tissue originated adipocytokines may play role in pathogenesis of atherosclerosis. These adipocytokines may alter vascular homeostasis by effecting endothelial cells, arterial smooth muscle cells and macrophages. Vaspin is a newly described member of adipocytokines family. We aimed to investigate whether plasma vaspin level has any predictive value in coronary artery disease (CAD). Forty patients who have at least single vessel ≥ 70 % stenosis demostrated angiographically and 40 subjects with normal coronary anatomy were included to the study. The vaspin levels were measured from serum that is obtained by centrifigation of blood and stored at -20 oC by ELISA method. The length, weight and body mass index of patients were measured. Biochemical parameters including total cholesterol, low density lipoprotein, high density lipoprotein, creatinine, sodium, potassium, hemoglobine, uric acid and fasting glucose were also measured. Biochemical markers levels were similar in both groups. Serum vaspin levels were significantly lower in CAD patients than control group (respectively; 256 ± 219 pg/ml vs. 472 ( 564 pg/ml, P < 0.02). Beside this serum vaspin level was lower in control group with high systolic blood pressure. Serum vaspin levels were found significantly lower in patients with CAD than age-matched subjects with normal coronary anatomy. Vaspin may be used as a predictor of CAD. Coronary artery disease; Vaspin; Adipokine