Potential anti-gout constituents as xanthine oxidase inhibitor from the fruits of Stauntonia brachyanthera
Potential anti-gout constituents as xanthine oxidase inhibitor from the fruits of Stauntonia brachyanthera
复制标题
野木瓜果实中作为黄嘌呤氧化酶抑制剂的潜在抗痛风成分
DOI：
10.1016/j.bmc.2017.05.010
复制
发表时间：
2017
影响因子：
3.5
通讯作者：
Meng Dali
中科院分区：
文献类型：
--
作者：
Liu Dan;Wang D;an;Yang Wei;Meng Dali
为寻找具有抗痛风作用的黄嘌呤氧化酶抑制剂，从野木瓜果实中分离得到12个苷类化合物，其中包括4个新的去甲齐墩果烷型三萜。它们的结构通过综合光谱（NMR和HR MS）分析确定。其中2个化合物（4和11）对黄嘌呤氧化酶有明显的抑制作用，IC 50值分别为5.22和1.60 μM。另外5个化合物（1、2、3、8和10）显示出合格的活性。结果表明，山茱萸果实中的降齐墩果烷型三萜和黄酮类化合物对黄嘌呤氧化酶具有抑制作用，从而阻断尿酸的生成。去甲齐墩果烷型三萜类化合物是一种新型的XO抑制剂，其作用机制值得在分子生物学水平上进一步研究。
With the aim of finding a better xanthine oxidase inhibitor with potential anti-gout properties, the studies on the fruit ofStauntonia brachyantherawere carried out, which led to the isolation of 12 glycosides, including 4 new nor-oleanane triterpenoids. Their structures were determined by comprehensive spectroscopic (NMR and HR MS) analysis. Two compounds (4and11) exhibited significant inhibitory activities on xanthine oxidase with IC50values of 5.22 and 1.60 µM, respectively. Another five compounds (1,2,3,8and10) showed qualified activities. The results suggested that the existences of nor-oleanane triterpenoids and flavonoids in the fruits were responsible for the inhibitory activity on xanthine oxidase that could cut off the production of uric acid. Nor-oleanane triterpenoids, a new leading XO inhibitor, is worthy of further studies on molecular biology level for its mechanisms.