Aurora A's Functions During Mitotic Exit: The Guess Who Game.
Aurora A's Functions During Mitotic Exit: The Guess Who Game.
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DOI：
10.3389/fonc.2015.00290
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发表时间：
2015
影响因子：
4.7
通讯作者：
Prigent C
中科院分区：
文献类型：
--
作者：
Reboutier D;Benaud C;Prigent C
直到最近，关于Aurora A激酶在有丝分裂过程中的功能的知识仅限于中期前事件，特别是中心体成熟，G2/M转变和有丝分裂纺锤体组装。然而，人们也怀疑极光A参与了中期后的事件，但由于进行适当实验的技术困难，没有明确证明。Aurora A的类似物特异性版本和小分子抑制剂的最新发展首次证明了Aurora A在细胞分裂的早期步骤中是必需的。与中期前期一样，极光A在后期发挥着多种功能，主要参与星体微管动力学和中央纺锤体组装和功能。本文介绍了用于破译有丝分裂后期Aurora A新功能的实验系统，并将这些功能置于细胞分裂机制的背景下。
Until recently, the knowledge of Aurora A kinase functions during mitosis was limited to pre-metaphase events, particularly centrosome maturation, G2/M transition, and mitotic spindle assembly. However, an involvement of Aurora A in post-metaphase events was also suspected, but not clearly demonstrated due to the technical difficulty to perform the appropriate experiments. Recent developments of both an analog-specific version of Aurora A and small molecule inhibitors have led to the first demonstration that Aurora A is required for the early steps of cytokinesis. As in pre-metaphase, Aurora A plays diverse functions during anaphase, essentially participating in astral microtubules dynamics and central spindle assembly and functioning. The present review describes the experimental systems used to decipher new functions of Aurora A during late mitosis and situate these functions into the context of cytokinesis mechanisms.