Selective attachment and release of a chemotherapeutic agent from the interior of a protein cage architecture
Selective attachment and release of a chemotherapeutic agent from the interior of a protein cage architecture
复制标题
DOI：
10.1039/b413435d
复制
发表时间：
2005-01-28
影响因子：
4.9
通讯作者：
Douglas, T
中科院分区：
文献类型：
--
作者：
Flenniken, ML;Liepold, LO;Douglas, T
抗肿瘤药物阿霉素以共价键结合的方式，并以依赖pH值的方式从一种经基因改造的小分子热休克蛋白（Hsp）笼的内表面选择性地释放出来。
The antitumor agent doxorubicin was covalently bound and selectively released in a pH dependent manner from the interior surface of a genetically modified small heat shock protein (Hsp) cage.